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Start (or continue) going to TA sections

Start (or continue) going to TA sections. Come to R ’ s and/or TAs office hours 2130 Pac Hall Tu 2:30-3:30 W 2: 30 -3: 30 . details on course web site:. http://course.ucsd.edu/rhampton/bibc102. Please. Please. READ Glucose, Glycolysis and Krebs. But First. Please.

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Start (or continue) going to TA sections

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  1. Start (or continue) going to TA sections Come to R’s and/or TAs office hours 2130 Pac Hall Tu2:30-3:30 W 2:30-3:30 details on course web site: http://course.ucsd.edu/rhampton/bibc102

  2. Please Please READ Glucose, Glycolysis and Krebs

  3. But First Please READ First Half of The NAME GAME

  4. READ Glucose, Glycolysis and Krebs hppt://courses.ucsd.edu/rhampton/bibc102

  5. Things to do with glucose… fig 14-1

  6. adenosine triphosphate… ATP

  7. fig 13-11

  8. 11kg 68kg In metabolism, it is all about the coupling mechanism free energies are additive! riddle: how do you lift 11 kg? ans: lower a weight > 11kg!

  9. fig 13-9

  10. It takes ATP to make ATP! the preparatory phase fig 14-2

  11. delayed gratification in glycolytic catabolism the payoff phase fig 14-2

  12. Glucose catabolism around the bios… fig 14-3

  13. Phosphorylation of glucose pg 532

  14. Hexokinse: an example of induced fit fig 6-22

  15. Hexokinse: an example of induced fit fig 6-22

  16. Isomerization of glucose 6-P pg 532

  17. Anomers… rh

  18. The structural simplicity of isomerase reaction rh

  19. Phosphorylation of fructose 6-P pg 532

  20. Cleavage of fructose 1,6 bisphosphate by aldolase pg 533

  21. Cleavage of fructose 1,6 bisphosphate by aldolase now have two distinct 3-carbon molecules fig 14-6

  22. DHAP isomerization gives us 2 identical G3P pg 534

  23. Isomerase action is familiar… same chemistry, different enzyme

  24. Equivalent carbons from different parts of glucose fig 14-6

  25. A fancy redox reaction… pg 535

  26. A fancy redox reaction catalyzed by GAPDH fig 14-7

  27. The GAPDH active site fig 14-7

  28. Enyzme-substrate complex fig 14-7

  29. a covalent intermediate between a cysteine S and the substrate fig 14-7

  30. The carbon molecule gets oxidized!! fig 14-7

  31. Phosphate as a nucleophile!!?? fig 14-7

  32. release of the product, 1,3 BPG fig 14-7

  33. Ready for more substrate… fig 14-7

  34. This is the product of interest! fig 14-7

  35. Voila! Our first ATP! XX pg 537

  36. Substrate level phosphorylation: the general idea

  37. “Isomerization” of 3PG to make 2PG “mutase” is isomerase that moves groups pg 537

  38. A low level intermediate must be produced fig 14-8 (fourth)

  39. Making an enol form by removal of H2O pg 538

  40. A second substrate level phosphorylation: more ATP! pg 538

  41. Ta Da!!! Pyruvic acid pg 538

  42. LDH converts pyruvate to lactate, restoring the pool of NAD+ pg 547

  43. neutrophil Glycolysis: energy without O2 anaerobic organisms anaerobic situations

  44. CEOLACANTH: the Living Fossil

  45. Glycolysis in action: 100 mt sprint Usain Bolt!!

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