1 / 1

100

300. 250. 200. [ ] NO x - µmol/l. 150. 100. 50. 0. 5 ’. 10 ’. 15 ’. Time (minutes). *. [ ] NO x - µmol/l. HPMC. HPMC + GSNO 1mM. A. B.

layne
Télécharger la présentation

100

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 300 250 200 [ ] NOx- µmol/l 150 100 50 0 5’ 10’ 15’ Time (minutes) * [ ] NOx- µmol/l HPMC HPMC + GSNO 1mM A B Supplementary Figure 1. Capacity of exogenous GSNO in achieving intraocular sites. A. NOx- concentrations measured by NOA chemiluminescence (Nitric Oxide Analyser) method from aqueous humour after 60 minutes of eye drop (GSNO 1mM) instillation at 15’, 30’, 45’ and 60’; p=0.003. B. Kinetics of the GSNO absorption in vitreous after 5’, 10’ and 15’ of instillation of GSNO eye drop evaluated by NOA chemiluminescence. The curve shows the concentration of NOx- (µmol/l). It was observed an increase in NOx- levels on aqueous humor and vitreous after topical administration of GSNO demonstrating that GSNO is able to cross the ocular barriers. These observations show that NOx- is rapidly detected in anterior chamber (aqueous humour) and also inside the vitreous with a rapidly decrease in its concentration

More Related