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A. B. pSrp TUCAN3. pSrp Control. WT. 120. 100. *. Non-specific. TUCAN. 80. 60. % of RNA expression. ß- actin. 40. 20. 0. pSrp TUCAN3. pSrp Control. C. D. LEHD-AFC cleavage. 3. 30. H460 WT. H460 WT. H460 pSrp Control. 2,5. H460 pSrp Control. 25. H460 pSrpTUCAN3.
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A B pSrp TUCAN3 pSrp Control WT 120 100 * Non-specific TUCAN 80 60 % of RNA expression ß-actin 40 20 0 pSrp TUCAN3 pSrp Control C D LEHD-AFC cleavage 3 30 H460 WT H460 WT H460 pSrp Control 2,5 H460 pSrp Control 25 H460 pSrpTUCAN3 H460 pSrpTUCAN3 2 20 % of sub G1 population 1.5 15 fold of control 1 10 0,5 5 0 0 48h etoposide untreated 48h untreated 48h cisplatin