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Three Dimensional Patient-Specific Intrathecal Infusion Model

Three Dimensional Patient-Specific Intrathecal Infusion Model. Ying Hsu March 31 st , 2011 Laboratory for Product and Process Design (LPPD) Advisor: Dr Andreas Linninger. Patient-specific Medicine. Rostral-caudal velocity. Anterior-posterior velocity. CSF flow. Image Reconstruction.

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Three Dimensional Patient-Specific Intrathecal Infusion Model

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  1. Three Dimensional Patient-Specific Intrathecal Infusion Model Ying Hsu March 31st, 2011 Laboratory for Product and Process Design (LPPD) Advisor: Dr Andreas Linninger

  2. Patient-specific Medicine Rostral-caudal velocity Anterior-posterior velocity CSF flow Image Reconstruction Patient-specific anatomy

  3. Accurate Computational Mesh for Recreating Cerebrospinal Fluid Flow Validation with Cine MRI flow measurements 3D Computational mesh: Brian Henry and May Kaewken

  4. Effect of Trabeculae on Drug Dispersion May Kaewken, LPPD

  5. Performing Virtual IT Drug Infusion with a Click… • You could try various: • Infusion rate • Dosage • Infusion site • Heart rate

  6. Drug Transport and Binding Gould and Hsu

  7. After 30 second Gould and Hsu

  8. Prediction of Drug-Receptor Binding Inside the Spinal Cord Tissue Prediction of morphine binding to receptors based on clinical data Image of the spinal cord Drug Dispersion Drug Action Collaborator: Jaimie Stewart

  9. Eliminating the ‘Unpredictability’ of intrathecal drug spread Stienstra & Greene, 1991

  10. Intrathecal Infusion Predictive Model • Test infusion on virtual patient • Optimize dosage • Assess potential toxicity • Predict drug dispersion a priori

  11. Summary • 3D computational spine model is ready for simulation • Learned from 2D qualitative model • We expect 3D model to be quantitative • Facing the challenge in predicting IT spread • Predict drug dispersion pattern • Coupling transport with receptor binding • Predict drug action & therapeutic effect • Validation with clinical measurements every step

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