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Health Effects of Pesticides on the Nervous System. Pesticide Health Effects Medical Education Database (PHEMED). Paresthesias Headache Behavioral-mood disturbances Depression/stupor/ coma/respiratory failure Seizures. Muscle twitching Tetany, carpopedal spasms Tremor
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Health Effects of Pesticides on the Nervous System Pesticide Health Effects Medical Education Database (PHEMED)
Paresthesias Headache Behavioral-mood disturbances Depression/stupor/coma/respiratory failure Seizures Muscle twitching Tetany, carpopedal spasms Tremor Incoordination/ataxia Paresis, muscle weakness Hypotensive shock Hypertension Pesticide Induced Signs and Symptoms
Pyrethroids- cyno group (I) – facial Organophosphates (I) Organochlorines (I) Phosphides (R) Thiobendazole (Asc) Nicotine (late) Inorganic arsenicals (I) Organic mercury (F) Sodium fluoroacetate (R) Carbon disulfide (Fum) Thallium – painful (R) Paresthesias Facial - Transitory Extremities
OP-Carbamates (I) Nicotine (I) Metallic compounds (F): mercury, cadmium, copper, organotin Thallium (R) Fluoride (I) Borates (I) Naphthalene (moth balls) Phosphine (Fum) Halocarbon fumigants Creosote (wood preservative) Diquat (H) Cholecalciferol (R) Cyanamid (Fum) Headachea common health outcome of pesticide exposure
Organic mercury (F) Inorganic arsenicals (F) Organotin cmpds (F) Thallium (R) Nicotine (I) Sodium fluoroacetate (R) Diquat (H) Cyanide (Fum) Nitrophenols (H) Aminopyridine (bird bait) Methylbromide (Soil fumigant - potatoes) Carbon disulfide (Fum) Behavioral-mood disturbancesconfusion, excitement, mania, disorientation, emotional lability
Depression, Stupor, Coma, Respiratory Failurewithout Convulsions • Organophosphates (OP’s) • Carbamates • Sodium Fluoride (Fum) • Borate • Diquat
Rodenticides Strychnine – (R) Crimidine – (R) Sodium fluoroacetate (R) Cyamide – (R) Thallium – (R) Insecticides Organochlorines (I) Nicotine (I) Fluoride (I) Chlorobenzilate (Asc) Metaldehyde –(slug bait) Fumigants Acrylonitrile (Fum) Carbon disulfide (Fum) Phosphine (Fum) Herbicides Sodium chlorate (H) Endothall (H) Disinfectants Povidone-iodine (D) Hexachlorophene (D) DEET (repellant) Seizures R-Rodenticide I-Insecticide D-Disinfectant Asc-Ascaride Fum-Fumigant H-Herbicide F- Fungicide
OP’s Carbamates Nicotine Sulfuryl fluoride (Fum) Organic mercury Thallium OPs Carbamates Nicotine Metaldehyde (slug bait) Borates (roach and ant control) Involuntary Muscle Movements Fasciculations Tremors
Halocarbon fumigants Ops Carbamates Carbon disulfide Nicotine Thallium Inorganic arsenicals OP’s Carbamates Nicotine Incoordination & Muscle Weakness Ataxia – Incoordination Paralysis/Paresis
Thallium (early) Nicotine (early) OP’s Phosphorus Phosphides Phosphine Sodium fluoride Sodium chlorate Borate Thallium Endothall Cyanamide Neurological Effects on the Circulatory System Hypertension Hypotensive Shock