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Health Effects of Pesticides on the Nervous System

Health Effects of Pesticides on the Nervous System. Helen Murphy – FNP, MHS Pacific Northwest Agricultural Safety and Health Center (PNASH) School of Public Health University of Washington. Paresthesias Headache Behavioral-mood disturbances Depression/stupor/ coma/respiratory failure

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Health Effects of Pesticides on the Nervous System

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  1. Health Effects of Pesticides on the Nervous System Helen Murphy – FNP, MHS Pacific Northwest Agricultural Safety and Health Center (PNASH) School of Public Health University of Washington

  2. Paresthesias Headache Behavioral-mood disturbances Depression/stupor/ coma/respiratory failure Seizures Muscle twitching Tetany, carpopedal spasms Tremor Incoordination/ataxia Paresis, muscle weakness Hypotensive shock Hypertension Central and Peripheral Nervous System: Pesticide Induced Signs and Symptoms

  3. Pyrethroids- cyno group (I) – facial Organophosphates (I) Organochlorines (I) Phosphides (R) Thiobendazole (Asc) Nicotine (late) Inorganic arsenicals (I) Organic mercury (F) Sodium fluoroacetate (R) Carbon disulfide (Fum) Thallium – painful (R) Paresthesias Extremities Facial - transitory

  4. OP-Carbamates (I) Nicotine (I) Metallic compounds (F): mercury, cadmium, copper, organotin Thallium (R) Fluoride (I) Borates (I) Naphthalene (moth balls) Phosphine (Fum) Halocarbon fumigants Creosote (wood preservative) Diquat (H) Cholecalciferol (R) Cyanamid (Fum) Headachea common health outcome of pesticide exposure

  5. Organic mercury (F) Inorganic arsenicals (F) Organotin cmpds (F) Thallium (R) Nicotine (I) Sodium fluoroacetate (R) Diquat (H) Cyanide (Fum) Nitrophenols (H) Aminopyridine (bird bait) Methylbromide (Soil fumigant - potatoes) Carbon disulfide (Fum) Behavioral-mood Disturbancesconfusion, excitement, mania, disorientation, emotional liability

  6. Depression, Stupor, Coma, Respiratory Failure without convulsions • Op’s • Carbamates • Sodium Fluoride (Fum) • Borate • Diquat

  7. Organochlorines (I) Strychnine – (R) Crimidine – (R) Sodium fluoroacetate (R) Nicotine (I) Cyamide – (R) Acrylonitrile (Fum) Metaldehyde –(slug bait) Thallium – (R) DEET (repellent) Chlorobenzilate (Asc) Carbon disulfide (Fum) Phosphine (Fum) Povidone-iodine (D) Hexachlorophene (D) Sodium chlorate (H) Endothall (H) Fluoride (I) Seizures R=Rodenticide I=Insecticide D=Disinfectant Asc=Ascaride Fum=Fumigant H=Herbicide F=fungicide

  8. OP’s Carbamates Nicotine Sulfuryl fluoride (Fum) Organic mercury Thallium OPs Carbamates Nicotine Metaldehyde (slug bait) Borates (roach and ant control) Involuntary Muscle Movements Fasciculations Tremors

  9. Halocarbon fumigants Ops Carbamates Carbon disulfide Nicotine Thallium Inorganic arsenicals OP’s Carbamates Nicotine Incoordination & Muscle Weakness Ataxia – Incoordination Paralysis/Paresis

  10. Thallium (early) Nicotine (early) OP’s Phosphorus Phosphides Phosphine Sodium fluoride Sodium chlorate Borate Thallium Endothall Cyanamide Neurological Effects on the Circulatory System Hypertension Hypotensive Shock

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