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HEART TRANSPLANTATION

HEART TRANSPLANTATION. Overall. NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR. *. Number of Transplants. * Numbers may be low due to delayed reporting. HEART TRANSPLANTS: Donor Age by Year of Transplant. AGE DISTRIBUTION OF HEART RECIPIENTS (1982-2001). % of Tr a nsplants. 1985-1996.

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HEART TRANSPLANTATION

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  1. HEART TRANSPLANTATION Overall

  2. NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR * Number of Transplants * Numbers may be low due to delayed reporting.

  3. HEART TRANSPLANTS: Donor Age by Year of Transplant

  4. AGE DISTRIBUTIONOF HEART RECIPIENTS(1982-2001) % of Transplants

  5. 1985-1996 1997-2001 AGE DISTRIBUTION OF HEART TRANSPLANT RECIPIENTS BY ERA

  6. HEART TRANSPLANTATION Actuarial Survival(1982-2001) Half-life = 9.3 years Conditional Half-life = 11.8 years N=60,936

  7. HEART TRANSPLANTATION Adult Recipients

  8. DIAGNOSIS IN ADULT HEART TRANSPLANTS

  9. ADULT HEART TRANSPLANTATIONActuarial Survival by Era (1982-2001) Survival (%) All comparisons significant at p < 0.002

  10. ADULT HEART TRANSPLANTATION Actuarial Survival by Age Group(1982-2001) Survival (%) Survival comparisons All pair-wise comparisons are statistically significant at p < 0.05 except: 18-34 vs. 35-49 and 65-69 vs. 70+

  11. 271 124 170 32 32 31 29 64 88 35 95 22 ADULT HEART RE-TRANSPLANTS1-Year Survival

  12. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=13,049

  13. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=13,049

  14. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049

  15. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049

  16. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049

  17. ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049

  18. ADULT HEART TRANSPLANTS (1996-2001)Factors Not Significant for 1 Year Mortality • Year of Transplant • In ICU or hospital prior to transplant • On inotropes for life support • ICD • CMV mismatch • Recipient pregnancy status • Weight (donor or recipient) • Height (donor) • Donor clinical infection • Donor cause of death

  19. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityIn Descending Order of Magnitude N=9,519

  20. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519

  21. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519

  22. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519

  23. ADULT HEART TRANSPLANTS(April 1994-December 1996)Factors Not Significant for 5 Year Mortality • Year of Transplant • VAD/ECMO/IABP • In ICU or hospital prior to transplant • On inotropes for life support • CMV mismatch • Recipient pregnancy status • Weight (donor or recipient) • Height (donor) • Donor clinical infection • Donor history of hypertension

  24. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearIn Descending Order of Magnitude N=7,738

  25. ADULT HEART TRANSPLANTS(April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearContinuous Factors N=7,738

  26. ADULT HEART TRANSPLANTS(April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearContinuous Factors N=7,738

  27. ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year:Combination of Donor Age and Center Volume

  28. ADULT HEART TRANSPLANTS(April 1994-December 1996)Factors Not Significant for Conditional 5 Year Mortality

  29. ADULT HEART RECIPIENTS Functional Status (April 1994-December 2001)

  30. ADULT HEART RECIPIENTS Employment Status(U.S. Data: April 1994-December 2001)

  31. ADULT HEART RECIPIENTSRehospitalization Post-transplant(April 1994 - December 2001)

  32. ADULT HEART RECIPIENTSInduction Immunosuppression For follow-ups between October 1999 and December 2001

  33. ADULT HEART RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

  34. ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001

  35. ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 3,165) 5 Year Follow-up (N = 2,588)

  36. ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001

  37. POST-HEART TRANSPLANT MORBIDITY FOR ADULTSCumulative Incidence for Survivors (April 1994-December 2000)

  38. Freedom from CAV and Freedom from Renal Dysfunction*For Adult Heart Recipients(April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

  39. MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTSCumulative Incidence for Survivors(April 1994-December 2001)

  40. Freedom from MalignancyFor Adult Heart Recipients(April 1994-December 2000)

  41. ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998) N=6,851

  42. ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998)Continuous Factors N=6,851

  43. ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998)Continuous Factors N=6,851

  44. ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 7 Years(April 1994 - December 1995) N=2,546

  45. ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 7 Years(April 1994 - December 1995)Continuous Factors N=2,546

  46. ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death(1982-2001) Timing of Death

  47. ADULT HEART TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 0-30 Days Year of Transplant

  48. ADULT HEART TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 31 Days-1 Year Year of Transplant

  49. ADULT HEART TRANSPLANTS RECIPIENTS:Cause of Death by Era: Deaths in >1 Year - 3 Years Year of Transplant

  50. ADULT HEART TRANSPLANTS RECIPIENTS:Cause of Death by Era: Deaths in >3 Years - 5 Years Year of Transplant

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