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M/Z Cal Issues at high mass loadings Brett Palm Jimenez Group CU-Boulder

M/Z Cal Issues at high mass loadings Brett Palm Jimenez Group CU-Boulder. My problem: At very high mass loadings (~thousand ug /m 3 ), organic peak interference at various masses ( eg Ar , W) causes problems with the m/z cal.

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M/Z Cal Issues at high mass loadings Brett Palm Jimenez Group CU-Boulder

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  1. M/Z Cal Issues at high mass loadings Brett Palm Jimenez Group CU-Boulder My problem: At very high mass loadings (~thousand ug/m3), organic peak interference at various masses (egAr, W) causes problems with the m/z cal

  2. Example of Argon m/z 40 successive V-mode runs, high loadings start in r2349:

  3. Possible fixes (in no particular order): • Don’t use that mass, manually use another • May need separate ToDo waves for high and low mass loadings • Peak search factor • Changes the window where it searches for the peak • Change the value of Delta for that mass • Adjusts the number of points it tries to fit • Filter Bad Parameters in Step 4 • Find a threshold that you think defines the bad fits • Choose replacement method • Interpolate • Repeat last good fit • Use logging (from DAQ, probably not recommended for most apps) • Make sure “# runs where fit = nan” is zero before you hit ‘End’

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