Effects of IFN-γ and MIBG on Caspase-3 Activity in STC-1 Cells

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This study investigates the impact of interferon gamma (IFN-γ) and the MIBG compound on caspase-3 activity in STC-1 cells. Variations in IFN-γ concentrations (10, 50, 100 U/ml) and MIBG concentrations (1, 10, 20 µM) were tested to assess their effects on apoptosis, as indicated by changes in caspase-3 activity. The results show potential interactions between IFN-γ and MIBG that may influence cell survival and apoptosis. Understanding these mechanisms is crucial for therapeutic applications involving apoptosis regulation.

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May 06, 2026

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1 ifn 2 mibg 3 caspase3 4 stc1 cells 5 apoptosis 6 cell survival 7 concentration effects 8 therapeutic applications text

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Effects of IFN-γ and MIBG on Caspase-3 Activity in STC-1 Cells

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A * * STC-1 * BON 150 caspase-3 activity [% of control] 100 50 0 10 250 500 100 IFN [U/ml] B BON 200 * 150 * caspase-3 activity [% of control] 100 50 0 IFN (10U/ml) + MIBG (10µM) 10 100 10 20 MIBG [µM] IFN [U/ml] IFN (10U/ml) + MIBG (20µM) IFN (100U/ml) + MIBG (10µM) IFN (100U/ml) + MIBG (20µM) C STC-1 * 150 100 caspase-3 activity [% of control] 50 0 IFN (10U/ml) + MIBG (1µM) 10 50 1 2 MIBG [µM] IFN [U/ml] IFN (10U/ml) + MIBG (2µM) IFN (50U/ml) + MIBG (1µM) IFN (50U/ml) + MIBG (2µM)