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Effects of Estrogen and Anti-p75 Treatment on JNK Activity After Lesion in OVX Female Rats

This study investigates the influence of estrogen and anti-p75 treatment on the activation of JNK pathways (pJNK1 and pJNK2) following neuronal lesions in ovariectomized (OVX) female rats. The experimental groups included different combinations of OVX, estrogen treatment, lesions, and control (sham) procedures, with assessments made at 6 and 24 hours post-injury (hpi). Results indicate notable changes in optical density related to JNK activation, suggesting potential therapeutic implications for neuroprotection and recovery following neural damage.

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Effects of Estrogen and Anti-p75 Treatment on JNK Activity After Lesion in OVX Female Rats

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  1. OVXESTROGEN SHAM LESION LESION SHAM LESION LESION + VEH + aP75 + VEH + aP75 OVXESTROGEN SHAM LESION LESION SHAM LESION LESION + VEH + aP75 + VEH + aP75 pJNK2 pJNK1 JNK2 JNK1 6 hpi 24 hpi * ** 0.4 0.3 pJNK2/JNK2 Optical Density * 0.2 0.1 0.0 Sham Lesion+Veh Lesion+Anti p75 Sham Lesion+Veh Lesion+Anti p75 Sham Lesion+Veh Lesion+Anti p75 Sham Lesion+Veh Lesion+Anti p75 OVX OVX+E OVX OVX+E 6 hpi 24 hpi

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