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Explore the impact of Beclin-1 and ATG7 modulation on Viability, Apoptosis Pathways, mRNA Expression, HSP72/73, p-Akt, p-mTOR, Hsp70/72, Active Caspase-3, and TS in H1299 cells. Investigate the effects of 3MA, Pem, ITF2357, and untreated conditions.
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Figure S3 A B C H1299 shBeclin1 H1299/siATG7 H1299 shCont H1299/Cont TS mRNAexpression (foldchange) Beclin1 ATG7 HSP72/73 HSP72/73 D E 3MA - + p-Akt Viability (%) Hsp70/72 p-mTOR * Hsp70/72 F Pem ITF2357 ITF2357 untreated • Pem H1299 N°ofEvents H1299 shBeclin-1 PE ActiveCaspase-3 staining Pem-> ITF2357 Pem ITF2357 untreated