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Influenza: Respiratory Virus

Influenza: Respiratory Virus

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Influenza: Respiratory Virus

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Presentation Transcript

  1. Influenza: Respiratory Virus Do Now:

  2. Important Characteristics • RNA virus • H & N refer to different versions of viral proteins. • ~100 nm (0.1 μm) diameter. spherical

  3. Transmission: Aerosol or hand-mouth

  4. Step 1: Hemagglutinin Protein Binds to Epithelial Cell in Nose or Lungs H Protein Lung Cell

  5. Hemagglutinin • http://biology.kenyon.edu/BMB/Chime2/2005/Cerchiara-Holsberry/FRAMES/start.htm

  6. Step 2: Endocytosis of Virus by Cell

  7. Step 2: another view

  8. Step 3: Viral Genes Enter Cytoplasm

  9. Step 4: vRNA Enters Nucleus, Begins making virus materials • vRNA and vRNA polymerase begin copying the virus genes. • Viral genes produce proteins that take over the cell: • Break down cell mRNAs for parts • Use the nucleotides to copy genetic material • Build proteins with cell ribosomes for new viruses

  10. Step 5: Virus Assembly

  11. Step 6: Release of Viruses

  12. 6 Steps of Viral Infection • Attachment • Endocytosis • Unpackaging • Viral Synthesis • Assembly • Release