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Gastrointestinal system

Gastrointestinal system. SYLLABUS: RBP( Robbins Basic Pathology ) Chapter : The Oral Cavity and the Gastrointestinal Tract. Gastrointestinal system. 72 Adamantinoma 74 Pleomorphic adenoma (parotid gland) 74 Adenoid cystic carcinoma (parotid gland) 288 Chronic gastritis

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Gastrointestinal system

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  1. Gastrointestinal system SYLLABUS: RBP(Robbins Basic Pathology) Chapter: TheOralCavity and theGastrointestinalTract

  2. Gastrointestinal system 72Adamantinoma 74 Pleomorphic adenoma (parotid gland) 74Adenoid cystic carcinoma (parotid gland) 288Chronic gastritis 184Gastric adenocarinoma 184a Mucionous adenocarcionoma Ulcerative colitis

  3. Adamantinoma Usual components in order from exterior to interior: - fibrous stroma - basement membrane - ameloblast monolayer - "stellate reticulum" (stratified stellate cells in myxoid material)

  4. Adamantinoma

  5. Adamantinoma

  6. Pleomorphic adenoma (= Mixed tumor) (parotid gland) The dominant histologic feature is the great heterogeneity: - epithelial elements resembling ductal cells or myoepithelial cells disposed in duct formations, acini, irregular tubules, strands, or sheets of cells - well-developed ducts lined by cuboidal to columnar cells with an underlying layer of deeply chromatic, small myoepithelial cells - strands or sheets of myoepithelial cells - islands of well-differentiated squamous epithelium - a mesenchyme-like background of loose myxoid tissue containing islands of chondroid and, rarely, foci of bone

  7. Pleomorphic adenoma

  8. Pleomorphic adenoma

  9. Adenoid cystic carcinoma (parotid gland) - small cells having dark, compact nuclei and scant cytoplasm disposed in tubular, solid, or cribriform patterns reminiscent of cylindromas arising in the adnexa of the skin - the spaces between the tumor cells often filled with a hyaline material thought to represent excess basement membrane

  10. Adenoid cystic carcinoma (parotid gland)

  11. Adenoid cystic carcinoma (parotid gland)

  12. Chronic gastritis - inflammatory infiltrate of lymphocytes and plasma cells within the lamina propria - lymphoid aggregates, some with germinal centers frequently observed within the mucosa - „active" inflammation signified by the presence of neutrophils within the glandular and surface epithelial layer Additional histologic features: - regenerative change - intestinal metaplasia: the antral, body, and fundic mucosa partially replaced by metaplastic columnar absorptive cells and goblet cells of intestinal morphology - atrophy: marked loss in glandular structures - dysplasia

  13. Chronic gastritis

  14. Chronic gastritis

  15. Chronic gastritis

  16. Gastric adenocarinoma - malignant neoplastic cells infiltrating the stomach wall - grading based on degree of gland formation

  17. Gastric adenocarinoma

  18. Gastric adenocarinoma

  19. Mucinous adenocarcinoma adenocarcinoma with the excessive mucin production generating large mucinous lakes

  20. Mucinous adenocarcinoma

  21. Mucinous adenocarcinoma

  22. Ulcerative colitis Inflammation: - a diffuse, predominantly mononuclear inflammatory infiltrate in the lamina propria- neutrophilic infiltration of the epithelial layer may produce collections of neutrophils in crypt lumina (crypt abscesses) Chronic mucosal damage Ulceration With remission: - granulation tissue- regeneration of the mucosal epithelium- submucosal fibrosis, mucosal architectural disarray and atrophy

  23. Ulcerative colitis

  24. Ulcerative colitis

  25. Ulcerative colitis

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