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NOX4 Expression and its Association with PSA Relapse in Primary Prostate Tumors

This study investigates the expression of NOX4 in primary prostate tumors and its potential association with prostate-specific antigen (PSA) relapse after radical prostatectomy. Using microarray analysis of macrodissected tissue samples from the same patient cohort, the expression levels of NOX4 mRNA were compared in tumors and histologically benign tissues. The results indicate that while there was no significant difference in expression levels across various Gleason scores, higher NOX4 mRNA levels were significantly associated with PSA relapse in patients (p = 0.026), highlighting its potential role as a biomarker for relapse.

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NOX4 Expression and its Association with PSA Relapse in Primary Prostate Tumors

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  1. NOX4/HPRT1 mRNA expression Supplemental Fig. 1 – Expression of NOX4 is associated with prostate-specific antigen (PSA) relapse in primary prostate tumors. The global gene expression profile of primary prostate tumors removed by radical prostatectomy was compared with histologically benign tissue obtained from the same patient cohort using microarray analysis of macrodissected tissue samples (Kuner et al. J Mol Med 2013;91:237–48). There was no significant difference in NOX4 expression levels between tumors compared with benign tissue or between high and low Gleason score tumors (not shown). However, NOX4 messenger RNA (mRNA) levels were significantly increased in the tumors of patients who experienced PSA relapse compared with those without relapse (p = 0.026, Mann-Whitney U; 19 subjects for no-relapse cases and 20 subjects for relapse cases; HPRT1 was used as housekeeping gene for calculation of relative expression levels).

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