1 / 13

Innate Immunity: Signaling via Toll-Like Receptors in Reactome

Innate Immunity: Signaling via Toll-Like Receptors in Reactome. Peter D’Eustachio June 11, 2012. Data model in a nutshell. Regulation. Input 1. Output 1. protein ( UniProt ) or m molecule ( ChEBI ) or complex ( GO/PRO ). Reaction. Input 2. Output 2. CatalystActivity

merv
Télécharger la présentation

Innate Immunity: Signaling via Toll-Like Receptors in Reactome

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Innate Immunity: Signaling via Toll-Like Receptors in Reactome Peter D’Eustachio June 11, 2012

  2. Data model in a nutshell Regulation Input 1 Output 1 protein (UniProt) or mmolecule (ChEBI) or complex (GO/PRO) Reaction Input 2 Output 2 CatalystActivity (GO mol function) location (GO cell component) Pathway (GO biol process) Pathway Reaction Reaction

  3. Data model details: working form of a protein, complex

  4. Web site home page (www.reactome.org)

  5. Divide reaction space into ~160 “canonical pathways”, each represented by an SBGN-like diagram

  6. Event hierarchy for Toll-like receptor signaling

  7. Early events in TLR4 signaling – details of a complex

  8. TLR4 signaling – functional interactors of CD14

  9. Functional interactors link TLR signaling pathways

  10. Credits OICR / CSHL Lincoln Stein Michael Caudy Marc Gillespie Robin Haw Bruce May Marija Orlic-Milacic Karen Rothfels Joel Weiser Guanming Wu EBI Henning Hermjakob Ewan Birney David Croft Antonio Fabregat-Mundo Phani Garapati Bijay Jassal Steve Jupe NYU Peter D'Eustachio Lisa Matthews Veronica Shamovsky EU 6th Framework Programme grant LSHG-CT-2005-518254 "ENFIN" NHGRI Grant # U41 HG003751

More Related