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Cancer & the Immune System

Cancer & the Immune System. Hugh B. Fackrell. Cancer & the Immune System. Assigned Reading Content Outline Performance Objectives Key terms Key Concepts Short Answer Questions. Assigned Reading. Janis Kuby’s Immunology 4th Ed Chapter: 22 pp 539-561 Janis Kuby’s Immunology 3rd Ed

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Cancer & the Immune System

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  1. Cancer & the Immune System Hugh B. Fackrell

  2. Cancer & the Immune System • Assigned Reading • Content Outline • Performance Objectives • Key terms • Key Concepts • Short Answer Questions

  3. Assigned Reading • Janis Kuby’s Immunology 4th Ed Chapter: 22 pp 539-561 • Janis Kuby’s Immunology 3rd Ed • Chapter: 24 pp 573-596

  4. Origins & Terms Malignant Transformation Tumours of the Immune System Tumour Antigens TATAs on human melanomas Immune Response to Tumours Tumour Evasion of Immune Response Cancer Immunotherapy Content Outline

  5. Origins & Terms

  6. Benign vs malignant

  7. Distribution of Cancer

  8. Diameter of Tumour (mm) Tumour Cell doubling Growth of Breast Cancer Death of Patient 1012cells Tumour first palpable 109cells Tumour visible by X rays 108cells

  9. Altered Growth Properties

  10. Localized Benign Tumour

  11. Tumour Invasion of Basal Lamina

  12. Metastasizes to Other Sites

  13. Tumour Antigens • Tumour specific Antigens • chemically induced • virally induced • Tumour associated antigens • oncofetal tumour antigens • oncogene proteins

  14. TSTA vs TATA

  15. Radio labelled anti CEA

  16. Genes for TSTAs

  17. Malignant Transformation • Oncogenes • Induction of cell proliferation • Inhibition of cell proliferation • Regulation of apoptosis

  18. Chromosomal translocations

  19. Tumour Induction

  20. Induction of Tumours

  21. Tumours of the Immune System

  22. TATAs on human melanomas

  23. TATAs on human melanomas

  24. Immunity to Polyoma virus(1)

  25. Immunity to Polyoma virus(2)

  26. Immunity to Polyoma virus (3)

  27. Immunity to Polyoma Virus (4)

  28. Immune Response to Tumours • NK cells & macrophages • Immune surveillance theory

  29. Tumour Evasion of Immune Response • Immunologic enhancement • Modulation of tumour antigens • Reduce MHC-I • No co-stimulatory signal

  30. Tumor Escape

  31. Cancer Immunotherapy • Modify Co-stimulatory signal • Enhance APC activity • Cytokine therapy • MABs • Tumour cell vaccines

  32. Allogenic/syngenic Transplant Breast cancer aplastic anemia leukemia ALL CML Myeolodysplasia multiple myeloma Non- Hodgkin’s lymphoma Hodgkin’s disease Autologous Transplants Leukemia AML ALL Multiple Myeloma Non Hodgkin’s lymphoma Hodkin’s disease Solid tumours Breast ovarian testicular Neuroblastoma Cancers Treatable by Bone Marrow Transplants

  33. Transfect co stimulartory signal

  34. Transfect with GM-CSF

  35. Lak cells & IL-2

  36. Mabs to B cell Lymphoma

  37. Transplant killed cells of MCA induced sarcoma A Challenge with Sarcoma A- No Growth Challenge with Sarcoma B- growth Transplant killed cells of Polyoma Virus induced sarcoma A Challenge with sarcoma A no growth challenge with sarcoma B no growth SV40 induced sarcoma C- growth Tumour Cell VaccineImmune Response to MCA or PV

  38. DONE!!!

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