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Effects of Resveratrol and Melatonin on Drosophila melanogaster Under Paraquat-Induced Oxidative Stress

This study investigates the impact of resveratrol and melatonin on the survival rates of Drosophila melanogaster subjected to paraquat-induced oxidative stress. With the increasing prevalence of alcohol-related disorders, understanding the role of antioxidants like resveratrol—found in grape skins—and melatonin may offer insights into enhancing survivability under oxidative conditions. The research aims to compare survival and lifespan between treated and control groups, testing the hypothesis that pre-exposure to these compounds will improve outcomes.

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Effects of Resveratrol and Melatonin on Drosophila melanogaster Under Paraquat-Induced Oxidative Stress

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  1. The Effects of Resveratrol and Melatonin on Drosophila melanogaster with Paraquat Induced Oxidative Stress By Anthony Anastasio

  2. Need Figure 1 Over the passed 6 years, disorders from alcohol have increased Figure 2 Wine still remains the leased consumed alcoholic beverage

  3. Oxidative stress

  4. Antioxidants

  5. Resveratrol • Found in the skin of grapes that are used in the fermentation of red wine. • Found in plants as a defense system against disease.

  6. Bass (2007) • When drosophila exposed to resveratrol, no increase in lifespan is shown Effect of Resveratrol on the Life span of C. Elegans

  7. Bauer (2004)

  8. Bonilla and Molero (2006) • Drosophila exposed to Melatonin, Serotonin, Lipoic acid, and Ascorbic acid The survivability of Drosophila shown after paraquat induced oxidative stress with different pre exposures

  9. Purpose • To determine the effects of resveratrol and melatonin on the survival rate of drosophila after paraquat induced oxidative stress.

  10. Hypothesis • Null Hypothesis- Drosophila will have the same survival rate after paraquat induced oxidative stress in all groups and no change in life span will occur. • Alternative Hypothesis- Drosophila that are pre-exposed to resveratrol and melatonin will have a higher survival rate after paraquat induced oxidative stress and a longer life span then the control group.

  11. Budget

  12. Do-ability • Drosophila cultures are available • Exposure to Resveratrol and Melatonin • Procedures that been done in lab

  13. Bibliography • Bonilla, Enrnesto. “Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid” 2006 <http://www.springerlink.com/content/t94348024gm18223/fulltext.pdf> • Goodwin, Tony. "Our Model: The Fruitfly Drosophila melanogaster." 14 Feb 2005 <http://www.anatomy.unimelb.edu.au/researchlabs/whitington/index.html#top>. • Hurst , Greg. "Insects, Sex and Parasites Group." http://www.ucl.ac.uk/~ucbtghu/Greg.htm • Kimball, John. "Drosophila melanogaster." 13 Nov 2002 <http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/D/Drosophila.html. • Mann, Chris. "tea: a cup full of health and happiness." Better Nutrition. 01 Mar 2007. 58. • Manning, Gerald. "A quick and simple introduction to Drosophila melanogaster." (2006) <http://www.ceolas.org/fly/intro.html>. • Roberfroid, Marcel. "Prebiotics: The Concept Revisited1,2." Journal of Nutrition. 3 2007. 830S. • Turner, Oliver. "Herbal Tea Benefits." 17 Mar 2006 <http://www.buzzle.com/editorials/3-14-2006-91095.asp>.

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