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The Complement System

The Complement System. Ricklin and Lambris 2007. Functions of the Complement System. •Viral neutralization. The Complement System. Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens

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The Complement System

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  1. The Complement System Ricklin and Lambris 2007

  2. Functions of the Complement System •Viral neutralization

  3. The Complement System Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens Designation of complement components: numerals (C1-C9) letter symbols (factor D) trivial names (homologous restriction factor) cleavage products – “a” and “b”

  4. Complement Activation Pathways Immunobiology (Garland Science 2005)

  5. The Complement System Complement Activation:

  6. The Complement System

  7. The Complement System Classical Pathway requires antibody interaction:

  8. The Complement System

  9. Consequences of Complement Activation •The three complement pathways converge at the membrane-attack complex (MAC).

  10. Consequences of Complement Activation

  11. Regulation of the Complement System Regulation can occur at multiple steps in the complement system: Before assembly of convertase activity After assembly of convertase Assembly of membrane attack complex (MAC) Turnberg and Botto, 2003

  12. Microbial Evasion •Some microbes can evade complement-mediated damage. Schneider, et al 2007

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