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COMPLEMENT SYSTEM. CELLULAR IMMUNITY. Doç. Dr. Gülderen Yanıkkaya Demirel. WHAT YOU WILL LEARN TODAY. LYMPHOCYTE MATURATION THYMUS and T CELLS MHC – MAJOR HISTOCOMPATABILITY COMPLEX TCR AND MHC INERACTION. LYMPHOCYTE DIFFERENTIATION. Cell Mediated and Humoral Immunity.
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CELLULAR IMMUNITY Doç. Dr. Gülderen Yanıkkaya Demirel
WHAT YOU WILL LEARN TODAY • LYMPHOCYTE MATURATION • THYMUS and T CELLS • MHC – MAJOR HISTOCOMPATABILITY COMPLEX • TCR AND MHC INERACTION
Cell Mediated and Humoral Immunity • Cell Mediated Immunity (Cellular Immunity), can be adoptively transferred only by viable T lymphocytes • Humoral immunity, can be adoptively transferred with serum containing antibodies.
Cell Mediated Immunity • General responses by CMI, include: • Facilitate innate immune response to bacteria • Anti-viral • Anti-fungal • Anti-tumor • Transplantationrejection
Apoptotic cells in red. • Macrophages in blue. ~ 98% of developing thymocytes undergo apoptosis.
DN1 DN2 DN3 “Double negative” CD3- 4- 8- 1st rearrangement Kit+ DN4 1 week CD3+ T cell Progenitor enters outer cortex- does not express markers Pre-TCR CD4+8+ “Double Positive” 2nd rearrangement
DN2 DN3
When the TCR finds MHC-Ag that is a fit the transient interaction becomes stabilized.
To complete T cell activation, costimulatorysignals are required. 3
CD28- on resting & activated T cells. • B7.1 & B7.2 on professional APC: • Dendritic cells • Activated macrophages & B cells. • Costimulatory signal & TCR interaction must be delivered by the same APC.