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Complement System

Complement System. Kalpita Mulye. Introduction. C1 – C9 Heat labile Soluble Glycoproteins Synthesis: hepatocytes , macrophages etc Initially inactive forms –req. activation (chemical transformations)- resulting in MAC

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Complement System

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  1. Complement System Kalpita Mulye

  2. Introduction • C1 – C9 • Heat labile • Soluble • Glycoproteins • Synthesis: hepatocytes, macrophages etc • Initially inactive forms –req. activation (chemical transformations)- resulting in MAC • Lysis, opsonization, clearance of immune complexes, activation of inflammatory response

  3. components of complement system

  4. The proteins of the classical pathway of complement activation.

  5. The proteins of the alternative pathway of complement activation.

  6. Structural similarity

  7. The terminal complement components

  8. Local inflammatory responses induction

  9. Regulation of complement activity

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