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雙節棍孢子植生蟲草 (Phytocordyceps ninchukispora Suet Wang) 屬麥角菌科，球

植生蟲草水溶性多糖體之成份及生理活性分析 eng Chemical composition and physiological activities of water-soluble polysaccharide from phytocordyceps ninchukispora Su et Wang. 雙節棍孢子植生蟲草 (Phytocordyceps ninchukispora Suet Wang) 屬麥角菌科，球 殼菌目，核菌綱，係最近於台灣發現新屬植生蟲草 (Phytocordyceps) 之單一種，本文

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雙節棍孢子植生蟲草 (Phytocordyceps ninchukispora Suet Wang) 屬麥角菌科，球

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  1. 植生蟲草水溶性多糖體之成份及生理活性分析engChemical composition and physiological activities of water-soluble polysaccharide from phytocordyceps ninchukispora Su et Wang • 雙節棍孢子植生蟲草(Phytocordyceps ninchukispora Suet Wang) 屬麥角菌科，球 • 殼菌目，核菌綱，係最近於台灣發現新屬植生蟲草(Phytocordyceps)之單一種，本文 • 仍以此菌株進行其多糖體成份之化學分析及其生理活性之研究，以液態培養法收集其 • 培養液經離心後取其上清液，利用超微過濾器，分子篩及離子交換法，純化其培養液 • 中之大分子多糖體，可分為水不溶性(PNI)及水可溶性(PNS)兩部份。本文仍針對水溶 • 性部份(PNS) 進行化學成分及生理活性分析。經以礦物酸(2N HCI)水解及三氟醋酸( • trifluoroacetic acid)水解顯示此一多糖，主要係由 N-acetylqlucosamine 組成， • 其水解物經 TMS做成衍生物後，以GC-mass分析得知，另含少量之Galactose， • Mannose 及 Threitol，以核磁共振光譜(NMR)顯示N-acetylqlucosamine，以β-1， • 4 方式鍵結。對小白鼠進行Sarcoma-180抗人工轉移測驗。顯示，在口服50 ㎎／kg • ／day 之劑量下，可減少肺臟腫瘤數至50％以下，以HL-60血癌細胞於體外培養顯示 • ，PNS可增加細胞群落數目，但沒有誘導細胞分化之功能，在同時與其他Cytokine • 比較之下，顥示其具有類似Cytokine 之性質。在Flow cytometry分析下，亦顥示PNS • 對於小白鼠週邊血液之Total T-1ymphocyte 及T-helper 1ymphocyte 有顥著提升的 • 作用。

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