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Understanding Hemoglobin: Synthesis, Types, Reactions, and Anemia

This comprehensive overview covers the synthesis and types of hemoglobin, including HbA, HbA2, HbA1c, HbF, Gower I, Gower II, methemoglobin, and sickle cell hemoglobin. Explore how hemoglobin reacts with oxygen, carbon dioxide, carbon monoxide, nitrogen oxide, and hydrogen ions. Gain insights into anemia, its causes, types, symptoms of iron deficiency anemia, and the impact of inherited disorders such as hemoglobinopathies and thalassemias. Understand the significance of peripheral blood film in diagnosing these conditions and the response to iron therapy.

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Understanding Hemoglobin: Synthesis, Types, Reactions, and Anemia

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  1. HEMOGLOBIN

  2. Synthesis of Hemoglobin

  3. Types of Haemoglobin • HbA ( Alpha2 Beta2) • HbA2 ( Alpha2 Delta2) • Hb A1c • HbF ( Alpha2 Gamma2) • Gower I ( Zeta2 Eeta2) • Gower II (Alpha2 Eeta2) • Met Hemoglobin • Hb S

  4. Sickle Cells

  5. Reactions of Hemoglobin • Combine with O2 • Combine with CO2 • Combine with CO • Combine with NO • Combine with H Ions

  6. Anemia Deficiency of haemoglobin content in the blood which can be caused by either too few RBCs or too little Hb in the cell for the age and sex of a patient.

  7. Types of Anemia

  8. Symptoms of Iron Deficiency Anemia • Kiolonychia • Angular cheil1osis

  9. The Development of Iron Deficiency Anemia

  10. Peripheral Blood Film Showing Iron deficiency Anemia

  11. Dimorphic blood film in Iron deficiency anaemia responding to Iron therapy

  12. Peripheral Blood Film Showing Megaloblastic Anemia

  13. Inherited Disorders of Hemoglobin • Hemoglobinopathies e.g Sickle cell anemia • Thalasemias e.g Alpha and Beta

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