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DNA Nanostructures and Patterning

DNA Nanostructures and Patterning . Taylor Stevenson Nucleic Acid Engineering February 15 th , 2011. Agenda. Structures Origami Branched Annealing Nanotubes Alternative Materials Patterning and Application Combing Origami as Scaffold Micropatterning Nanotubes. Origami Structures.

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DNA Nanostructures and Patterning

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  1. DNA Nanostructures and Patterning Taylor Stevenson Nucleic Acid Engineering February 15th, 2011

  2. Agenda • Structures • Origami • Branched Annealing • Nanotubes • Alternative Materials • Patterning and Application • Combing • Origami as Scaffold • MicropatterningNanotubes

  3. Origami Structures Rothemund “Folding DNA to create nano-scale shapes and patterns” Nature Articles (2006)

  4. Origami Structures Rothemund “Folding DNA to create nano-scale shapes and patterns” Nature Articles (2006)

  5. Branched Annealing Structures Modified from Luo et.al. Nature Letters 2006 5.

  6. Nano-Tube Structures Chen et. al. “Approaching The Limit: Can One DNA OligonucleotideAssemble into Large Nanostructures?” (2006)

  7. Other Forms of Nucleic Acid Braasch & Corey, Chemistry and Biology (2001)

  8. Other Forms of Nucleic Acid Lin et. al. “Mirror Image DNA Nanostructures for ChiralSupramolecularAssemblies” Nano Letters (2009)

  9. Combing Linear DNA for Nanowires Deng and Mao “DNA-TemplatedFabrication of 1D Parallel and 2D Crossed Metallic NanowireArrays” Nano Letters (2003)

  10. DNA Origami as a Scaffold • RNA/DNA hybridization assays Ke et. al. “Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays” Science (2008)

  11. DNA Origami as a Scaffold Ke et. al. “Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays” Science (2008)

  12. DNA Origami as a Scaffold Rinker et. al. “Self-assembled DNA nanostructures for distance-dependent multivalent ligand–protein binding” Nature Letters (2008)

  13. MicropatterningNanotubes Lin et. al. “Functional DNA Nanotube Arrays: Bottom-Up Meets Top-Down” AngeChem (2007)

  14. 2D Patterning Branched Annealing Structures

  15. 2D Patterning Branched Annealing Structures Rigidity of “monomers” affects 2/3D structure. Varying the length of red region produces different flexibilities.

  16. 2D Patterning Branched Annealing Structures Flexibility Stiffness

  17. 2D Patterning Branched Annealing Structures Flexibility Stiffness

  18. MicropatterningNanotubes

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