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Impact of Ribavirin and Corticosteroids on Mortality in Crimean-Congo Hemorrhagic Fever Patients

This study investigates the effects of ribavirin and corticosteroids on mortality rates in patients with confirmed Crimean-Congo hemorrhagic fever (CCHF) over a seven-year period (2004-2010) in Turkey. A retrospective analysis of 281 patients showed an overall mortality rate of 8.2%. Multivariable regression analysis indicated that ribavirin significantly reduces mortality in moderately severe cases, while corticosteroids are particularly beneficial for patients classified as severe. The findings suggest tailored treatment strategies based on disease severity.

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Impact of Ribavirin and Corticosteroids on Mortality in Crimean-Congo Hemorrhagic Fever Patients

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  1. 1 of 2 Impact of ribavirin and corticosteroids on mortality in patients infected with Crimean-Congo haemorrhagic fever (CCHF) virus Single-centre retrospective analysis (Turkey; 2004-2010) N=281 patients with confirmed diagnosis of CCHF Revision of existing severity scoring index*: criteria: Platelet count Bleeding Fibrinogen Activated partial thromboplastin time Somnolence Overall mortality rate: 23/281 = 8% Dokuzoguz B. ECCMID 2013 abs. O335 *Ergonul O et al. Clin Microbiol Infect 2006;12:551-4.

  2. 2 of 2 Impact of ribavirin and corticosteroids on mortality in patients infected with Crimean-Congo haemorrhagic fever (CCHF) virus • Multivariable regression analysis (adjusted for gender, age, days from onset of symptoms, ribavirin and steroid use): • Effect of ribavirin and corticosteroids on mortality (χ2 test adjusted for severity scoring index): • Ribavirin: Significant decrease of mortality in moderately severe patients • Steroids: Significant decrease of mortality in severe patients Ribavirin may decrease mortality in moderately ill patients with CCHF, while steroids may be especially beneficial for severe patients (with severity defined by a revised severity scoring index) Dokuzoguz B. ECCMID 2013 abs. O335

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