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Sildenafil Mitigates Remodeling in Hearts with Advanced Hypertrophy from Pressure Overload

This online appendix accompanies the January 13 JACC article, detailing how Sildenafil effectively halts progressive chamber, cellular, and molecular remodeling in hearts with pre-existing advanced hypertrophy due to pressure overload. The findings underscore Sildenafil's role in improving calcium handling and overall cardiac function. Authored by a team of experts, including Takahiro Nagayama, PhD, and David A. Kass, MD, this research provides valuable insights into novel therapeutic approaches for managing heart hypertrophy and dysfunction.

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Sildenafil Mitigates Remodeling in Hearts with Advanced Hypertrophy from Pressure Overload

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  1. OnlineAppendix for the following January 13 JACCarticle

  2. TITLE:Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

  3. AUTHORS:Takahiro Nagayama, PhD, Steven Hsu, BA, Manling Zhang, MD, PhD, Norimichi Koitabashi, MD, PhD, Djahida Bedja, MS, Kathleen L. Gabrielson, PhD, Eiki Takimoto, MD, PhD, David A. Kass, MD

  4. APPENDIX

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