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LUNG TRANSPLANTATION

LUNG TRANSPLANTATION

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LUNG TRANSPLANTATION

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  1. LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2007 J Heart Lung Transplant 2007;26

  2. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January 1986 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  3. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - PERCENTAGE(Transplants: January 1986 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  4. DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR PEDIATRIC LUNG RECIPIENTS (Transplants: 1986-2005) ISHLT NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of lung transplants worldwide has declined in recent years. 2007 J Heart Lung Transplant 2007;26

  5. DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  6. AGE DISTRIBUTION FOR DONORS OFPEDIATRIC LUNG RECIPIENTS(Transplants: January 1986 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  7. 84 85 82 AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTSBy Year of Transplant 72 77 71 70 67 66 66 59 51 46 47 43 Number of Transplants 20 6 3 4 1 ISHLT 2007 J Heart Lung Transplant 2007;26

  8. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT 2007 J Heart Lung Transplant 2007;26

  9. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME ISHLT 2007 J Heart Lung Transplant 2007;26

  10. PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1991 – June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  11. DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTSBY YEAR OF TRANSPLANTAge: 12-17 Years ISHLT 2007 J Heart Lung Transplant 2007;26

  12. PEDIATRIC LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  13. PEDIATRIC LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 • NOTE: Unknown diagnoses were excluded from this tabulation. • Total number of transplants reported: • Europe = 82 • North America = 338 • Other = 24 ISHLT 2007 J Heart Lung Transplant 2007;26

  14. PEDIATRIC LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 • NOTE: Transplants with unknown donor age were excluded from this tabulation. • Total number of transplants reported: • Europe = 82 • North America = 338 • Other = 24 ISHLT 2007 J Heart Lung Transplant 2007;26

  15. LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2005) P = 0.7878 ISHLT 2007 J Heart Lung Transplant 2007;26

  16. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2005) P < .0001 ISHLT 2007 J Heart Lung Transplant 2007;26

  17. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival for Congenital Diagnoses(Transplants: January 1990 – June 2005) Eisenmenger’s vs. Other: p = 0.19 ISHLT 2007 J Heart Lung Transplant 2007;26

  18. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  19. PEDIATRIC LUNG TRANSPLANTATIONConditional Kaplan-Meier Survival by Age Group(Transplants: January 1990 - June 2005) CONDITIONAL HALF-LIFE <1 Year: 8.8 Years 1-11 Years: 10.5 Years 12-17 Years: 5.8 Years ISHLT 2007 J Heart Lung Transplant 2007;26

  20. PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1988 - June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  21. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor Type for Recipients Age 11-17 Years(Transplants: January 1990 - June 2005) HALF-LIFE Deceased: 4.0 Years Living: 3.8 Years ISHLT 2007 J Heart Lung Transplant 2007;26

  22. PEDIATRIC LUNG RE-TRANSPLANTS Between January 1994 and June 2006 Time Between Previous and Current Transplant ISHLT 2007 J Heart Lung Transplant 2007;26

  23. PEDIATRIC LUNG RETRANSPLANTSSurvival for Transplants Performed Between January 1994 and June 2005 ISHLT 2007 J Heart Lung Transplant 2007;26

  24. PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients(Follow-ups: April 1994-June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  25. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  26. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  27. PEDIATRIC LUNG RECIPIENTS Induction ImmunosuppressionFor transplants between January 2001 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  28. PEDIATRIC LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2001 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  29. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival Stratified by Induction Use(Transplants: January 2001 - June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  30. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-up(Follow-ups: January 2001 and June 2006) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2007 J Heart Lung Transplant 2007;26

  31. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-up(Follow-ups: January 2001 and June 2006) 1 Year Follow-up (N = 210) 5 Year Follow-up (N = 112) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2007 NOTE: 5% of patients were on both calcineurin inhibitors at different point during the year; these patients are not counted in either group. In the 5-year tabulations, 14% were reported to be on both drugs during the year. J Heart Lung Transplant 2007;26

  32. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression Drug Combinations at Time of Follow-up Report (Follow-ups: January 2001 and June 2006) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2007 J Heart Lung Transplant 2007;26

  33. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  34. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  35. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  36. Freedom from Bronchiolitis ObliteransFor Pediatric Lung Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  37. FREEDOM FROM BRONCHIOLITIS OBLITERANSFor Pediatric Lung Recipients by Induction Use (Transplants: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  38. Freedom from Severe Renal Dysfunction*For Pediatric Lung Recipients(Follow-ups: April 1994 - June 2006) * Severe renal dysfunction = Creatinine > 2.5 mg/dl (221 μmol/L), dialysis or renal transplant ISHLT 2007 J Heart Lung Transplant 2007;26

  39. MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICSCumulative Incidence for Survivors(Follow-ups: April 1994 - June 2006) ”Other” includes Liver and primitive neuroectodermal tumor. ISHLT 2007 J Heart Lung Transplant 2007;26

  40. Freedom from MalignancyFor Pediatric Lung Recipients (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  41. PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death(Deaths: January 1992- June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  42. PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death(Deaths: April 1994- June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26