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LUNG TRANSPLANTATION

LUNG TRANSPLANTATION. Overall. ISHLT. 2008. J Heart Lung Transplant 2008;27: 937-983. 2196. 2168. 1924. 1789. 1788. 1615. 1574. 1481. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE. 1461. 1457. 1375. 1366. 1229. 1087. 923. 707. 418. 189. 83. 45. 15. 14.

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LUNG TRANSPLANTATION

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  1. LUNG TRANSPLANTATION Overall ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  2. 2196 2168 1924 1789 1788 1615 1574 1481 NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE 1461 1457 1375 1366 1229 1087 923 707 418 189 83 45 15 14 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  3. AVERAGE CENTER VOLUMELung Transplants: January 1, 2000 - June 30, 2007 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  4. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMELung Transplants: January 1, 2000 - June 30, 2007 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  5. LUNG TRANSPLANTS:Transplant Recipient Age by Year of Transplant ISHLT Transplants between January 1987 and June 2007 2008 J Heart Lung Transplant 2008;27: 937-983

  6. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS(1/1985-6/2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  7. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT Transplants with unknown recipient age were excluded from this tabulation. 2008 J Heart Lung Transplant 2008;27: 937-983

  8. LUNG TRANSPLANTS:Donor Age by Year of Transplant ISHLT Transplants between January 1987 and June 2007 2008 J Heart Lung Transplant 2008;27: 937-983

  9. DONOR AGE DISTRIBUTION FOR LUNG TRANSPLANTS(1/1985-6/2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  10. DONOR AGE DISTRIBUTION FOR LUNG TRANSPLANTS BY ERA ISHLT Transplants with unknown donor age were excluded from this tabulation. 2008 J Heart Lung Transplant 2008;27: 937-983

  11. LUNG TRANSPLANTATION Adult Recipients ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  12. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS(1/1985-6/2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  13. Mean age by era 1985-1995 = 45.0 years 1996-6/2006 = 49.1 years AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  14. Mean age by era 1985-1994 = 44.7 years 1995-1999 = 47.3 years 2000-6/2007 = 49.8 years AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  15. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1994 - June 2006) P < 0.0001 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  16. ADULT LUNG TRANSPLANTATION: Indications(1/1995-6/2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  17. ADULT LUNG TRANSPLANTATION: Distribution of Procedure Type for Major Indications(1992-2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  18. ADULT LUNG TRANSPLANTATIONProcedure Type within Indication, by Year ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  19. ADULT LUNG TRANSPLANTATION: Indications for Single Lung Transplants (Transplants: January 1995 - June 2007) *Other includes: Sarcoidosis: 2.1% Bronchiectasis: 0.4% Congenital Heart Disease: 0.2% LAM: 0.7% OB (non-ReTx): 0.5% Miscellaneous: 5.8% ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  20. ADULT LUNG TRANSPLANTATION: Indications for Bilateral/Double Lung Transplants (Transplants: January 1995 - June 2007) *Other includes: Sarcoidosis: 3.0% Bronchiectasis: 4.8% Congenital Heart Disease: 1.3% LAM: 1.2% OB (non-ReTx): 1.1% Miscellaneous: 6.6% ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  21. ADULT LUNG TRANSPLANTATIONIndications By Year (%) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  22. ADULT LUNG TRANSPLANTATIONIndications By Year (Number) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  23. ADULT LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2007 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  24. ADULT LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2007 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  25. ADULT LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2007 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  26. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Era (Transplants: January 1988 – June 2006) Survival comparisons by era 1988-94 vs. 1995-99: p = 0.0009 1988-94: vs. 2000-6/06: p <0.0001 1995-99 vs. 2000-6/06: p <0.0001 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  27. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group(Transplants: January 1990 – June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  28. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Gender(Transplants: January 1990 – June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  29. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. CF: p = 0.0003 CF vs. COPD: p < 0.0001 Alpha-1 vs. COPD: p = 0.0009 CF vs. IPF: p < 0.0001 Alpha-1 vs. IPF: p < 0.0001 CF vs. PPH: p < 0.0001 Alpha-1 vs. PPH: p = 0.0027 CF vs. Sarcoidosis: p < 0.0001 Alpha-1 vs. Sarcoidosis p = 0.0263 COPD vs. IPF: p <0.0001 Note: Other comparisons are not statistically different. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  30. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. CF: p = 0.0081 CF vs. Sarcoidosis: p = 0.0137 Alpha-1 vs. COPD: p < 0.0001 PPH vs. COPD: p < 0.0001 Alpha-1 vs. IPF: p < 0.0001PPH vs. IPF: p < 0.0001 Alpha-1 vs. PPH: p = 0.0094 PPH vs. Sarcoidosis: p = 0.0105 CF vs. COPD: p < 0.0001 COPD vs. IPF: p = 0.0319 CF vs. IPF: p < 0.0001IPF vs. Sarcoidosis: p = 0.0252 Note: Other comparisons are not statistically different. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  31. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. COPD: p < 0.0001 Alpha-1 vs. PPH: p = 0.0200 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 COPD vs. Sarcoidosis: p = 0.0001 IPF vs. Sarcoidosis: p = 0.0006 Note: Other comparisons are not statistically different. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  32. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. CF: p = 0.0003 Alpha-1 vs. COPD p = 0.0009 Alpha-1 vs. IPF p < 0.0001 Alpha-1 vs. PPH: p = 0.0027 Alpha-1 vs. Sarcoidosis: p = 0.0263 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 CF vs. PPH: p < 0.0001 CF vs. Sarcoidosis: p < 0.0001 COPD vs. IPF: p <0.0001 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  33. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. CF: p = 0.0081 Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. COPD: p < 0.0001 Alpha-1 vs. PPH: p = 0.0094 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 CF vs. Sarcoidosis: p = 0.0137 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 PPH vs. Sarcoidosis: p = 0.0105 COPD vs. IPF: p = 0.0319 IPF vs. Sarcoidosis: p = 0.0252 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  34. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2006) Survival comparisons Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. COPD: p < 0.0001 Alpha-1 vs. PPH: p=0.0200 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 COPD vs. Sarcoidosis: p = 0.0001 IPF vs. Sarcoidosis: p = 0.0006 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  35. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival for Eisenmenger’s Syndrome(Transplants: January 1990 – June 2006) N at risk= 35 p = 0.0860 N at risk = 14 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  36. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type(Transplants: January 1990 – June 2006)Diagnosis: Alpha-1 Antitrypsin Deficiency N at risk at 5 years = 303 N at risk = 80 N at risk at 5 years = 354 N at risk = 106 P = 0.0012 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  37. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type and Age (Transplants: January 1990 – June 2006)Diagnosis: Alpha-1 Antitrypsin Deficiency p = 0.0654 N at risk at 10 years: Single Lung, <50 = 67; Double Lung, <50 = 65; Single Lung, 50+ = 39; Double Lung, 50+ = 15 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  38. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2006) Diagnosis: Emphysema/COPD P < 0.0001 N at risk at 5 years = 580 N at risk at 5 years = 1,571 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  39. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Age(Transplants: January 1990 – June 2006) Diagnosis: Emphysema/COPD P < 0.0001 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  40. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type(Transplants: January 1990 – June 2006)Diagnosis: Idiopathic Pulmonary Fibrosis N at risk at 5 years = 196 N at risk at 5 years = 566 P = 0.0133 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  41. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2006)Diagnosis: Primary Pulmonary Hypertension P = 0.0051 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  42. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2006) Diagnosis: Emphysema/COPD, Single Lung ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  43. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2006) Diagnosis: Emphysema/COPD, Double Lung ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  44. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2006) Diagnosis: Idiopathic Pulmonary Fibrosis, Single Lung ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  45. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2006) Diagnosis: Idiopathic Pulmonary Fibrosis, Double Lung ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  46. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor CMV status/Recipient CMV status(Transplants: October 1999 – June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  47. ADULT LUNG TRANSPLANTS (1995-6/2006)Risk Factors for 1 Year Mortality (N=11,079) *Other = All diagnoses other than COPD, PPH, IPF, cystic fibrosis, pulmonary fibrosis,bronchiectasis,alpha-1 antitrypsin deficiency, and LAM. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  48. ADULT LUNG TRANSPLANTS (1995-6/2006)Risk Factors for 1 Year Mortality (N=11,079) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  49. ADULT LUNG TRANSPLANTS (1995-6/2006)Risk Factors for 1 Year Mortality (N=11,079) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  50. ADULT LUNG TRANSPLANTS (1995-6/2006)Borderline Significant Risk Factors for 1 Year Mortality (N=11,079) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

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