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LUNG TRANSPLANTATION

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LUNG TRANSPLANTATION. Overall. ISHLT. 2005. J Heart Lung Transplant 2005;24: 945-982. 1767. 1602. 1703. 1564. 1464. 1477. 1377. 1457. 1368. 1229. 1089. 922. 708. 418. 189. 83. 15. 46. 13. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE.

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  1. LUNG TRANSPLANTATION Overall ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  2. 1767 1602 1703 1564 1464 1477 1377 1457 1368 1229 1089 922 708 418 189 83 15 46 13 NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  3. AVERAGE CENTER VOLUMELung Transplants: January 1, 1998 - June 30,2004 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  4. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMELung Transplants: January 1, 1998 - June 30,2004 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  5. LUNG TRANSPLANTS:Donor Age by Year of Transplant ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  6. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS(1/1985-6/2004) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  7. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  8. LUNG TRANSPLANTATION Adult Recipients ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  9. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS(1/1985-6/2004) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  10. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  11. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1994 - June 2003) P < 0.0001 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  12. ADULT LUNG TRANSPLANTATION: Indications(1/1995-6/2004) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  13. ADULT LUNG TRANSPLANTATION: Distribution of Procedure Type for Major Indications(1990-2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  14. ADULT LUNG TRANSPLANTATIONProcedure Type within Indication, by Year 2005 J Heart Lung Transplant 2005;24: 945-982

  15. ADULT LUNG TRANSPLANTATION: Indications for Single Lung Transplants (Transplants: January 1995 - June 2004) *Other includes: Sarcoidosis: 2% Bronchiectasis: 0.7% Congenital Heart Disease: 0.2% LAM: 0.8% OB (non-ReTx): 0.6% Miscellaneous: 5% ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  16. ADULT LUNG TRANSPLANTATION: Indications for Bilateral/Double Lung Transplants (Transplants: January 1995 - June 2004) *Other includes: Re-Tx: 2% Congenital Heart Disease: 2% LAM: 1.3% OB (non-ReTx): 1.3% Miscellaneous: 5% ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  17. ADULT LUNG TRANSPLANTATIONIndications By Year (%) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  18. ADULT LUNG TRANSPLANTATIONIndications By Year (Number) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  19. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Era (Transplants: January 1988 – June 2003) Survival comparisons by era 1988-94 vs. 1995-99: p = 0.01 1988-94: vs. 2000-6/03: p <0.0001 1995-99 vs. 2000-6/03: p <0.0001 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  20. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group(Transplants: January 1990 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  21. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Gender(Transplants: January 1994 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  22. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1994 – June 2003) Survival comparisons COPD vs. IPF: p < 0.0001 Alpha-1 vs. CF: p = 0.0248 Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. PPH: p = 0.0021 CF vs. COPD: p = 0.0006 CF vs. IPF: p < 0.0001 CF vs. PPH: p < 0.0001 CF vs. Sarcoidosis: p = 0.0007 Note: Other comparisons are not statistically different. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  23. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1994 – June 2003) Survival comparisons Alpha-1 vs. IPF: p = 0.0015 Alpha-1 vs. COPD: p = 0.0073 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p = 0.0005 PPH vs. IPF: p = 0.0002 Note: Other comparisons are not statistically different. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  24. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1994 – June 2003) Survival comparisons Alpha-1 vs. IPF: p = 0.0103 Alpha-1 vs. COPD: p < 0.0001 CF vs. COPD: p < 0.0001 CF vs. IPF: p = 0.0012 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p = 0.0017 COPD vs. Sarcoidosis: p = 0.0102 IPF vs. Sarcoidosis: p = 0.0408 Note: Other comparisons are not statistically different. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  25. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1994 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  26. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1994 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  27. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1994 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  28. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival for Eisenmenger’s Syndrome(Transplants: January 1990 – June 2003) N at risk at 5 years = 33 N at risk at 5 years = 15 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  29. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type (Transplants: January 1990 – June 2003)Diagnosis: Alpha-1 Antitrypsin Deficiency P = 0.0007 N at risk at 10 years is 44 for Single Lung and 23 for Double Lung. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  30. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type and Median Age (Transplants: January 1990 – June 2003)Diagnosis: Alpha-1 Antitrypsin Deficiency p = 0.22 N at risk at 5 years: Single Lung, <50 = 140; Double Lung, <50 = 126; Single Lung, 50+ = 97; Double Lung, 50+ = 45 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  31. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2003) Diagnosis: Emphysema/COPD P < 0.0001 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  32. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Age(Transplants: January 1990 – June 2003) Diagnosis: Emphysema/COPD P < 0.0001 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  33. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2003)Diagnosis: Idiopathic Pulmonary Fibrosis P = 0.5 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  34. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2003)Diagnosis: Primary Pulmonary Hypertension P = 0.3 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  35. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2003) Diagnosis: Emphysema/COPD, Single Lung ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  36. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2003) Diagnosis: Emphysema/COPD, Double/Bilateral Lung ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  37. ADULT LUNG TRANSPLANTATIONActual Survival by Procedure Type and Era(Transplants: January 1990 – December 1999) Diagnosis: Emphysema/COPD, Double/Bilateral Lung ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  38. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2003) Diagnosis: Idiopathic Pulmonary Fibrosis, Single Lung ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  39. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2003) Diagnosis: Idiopathic Pulmonary Fibrosis, Double/Bilateral Lung ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  40. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor CMV status/Recipient CMV status(Transplants: October 1999 – June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  41. ADULT LUNG TRANSPLANTS (1995-6/2003)Risk Factors for 1 Year Mortality (N=11,291) *Other = All diagnoses other than COPD, PPH, IPF, CF, bronchiectasis,Alpha-1 antitrypsin deficiency, and LAM. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  42. ADULT LUNG TRANSPLANTS (1995-6/2003)Risk Factors for 1 Year Mortality (N=11,291) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  43. ADULT LUNG TRANSPLANTS (1995-6/2003)Risk Factors for 1 Year Mortality (N=11,291) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  44. ADULT LUNG TRANSPLANTS (1995-6/2003)Borderline Significant Risk Factors for 1 Year Mortality (N=11,291) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  45. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year Mortality ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  46. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year MortalityRecipient Age ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  47. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year MortalityDonor Age ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  48. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year MortalityDonor Weight ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  49. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year MortalityPre-Transplant Recipient BMI ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

  50. ADULT LUNG TRANSPLANTS(1/1995-6/2003)Risk Factors for 1 Year MortalityCenter volume ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982