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ADNI Biomarker Fluids Collection Procedures Manual Leslie M Shaw John Q Trojanowski

2. Biomarkers in Biofluids. Rationale:The development of valid and reliable biomarkers for AD is needed to:aid in the recognition of the illness at its earliest clinically recognizable stagesdetect the disease before dementia or other symptoms appeardistinguish AD from other causes of dementia

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ADNI Biomarker Fluids Collection Procedures Manual Leslie M Shaw John Q Trojanowski

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    1. 1 ADNI Biomarker Fluids Collection Procedures Manual Leslie M Shaw John Q Trojanowski

    2. 2 Biomarkers in Biofluids Rationale: The development of valid and reliable biomarkers for AD is needed to: aid in the recognition of the illness at its earliest clinically recognizable stages detect the disease before dementia or other symptoms appear distinguish AD from other causes of dementia especially valuable, together with imaging tests, in the evaluation of disease-modifying therapies

    3. 3 Biomarkers in AD fluids Promising biomarkers that will be measured in ADNI fluids: Tau in CSF Amyloid beta in CSF Isoprostanes in CSF, plasma, urine Homocysteine in plasma, CSF APO E genotyping-blood DNA from blood cells

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    9. 9 Visit Numbering

    10. 10 Screening Visit Vst 0

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    17. 17 Baseline Visit Vst 1

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    33. 33 NCRAD Procedure WHOLE BLOOD SPECIMENS and SAMPLING KIT FOR THE NATIONAL CELL REPOSITORY for ALZHEIMERS DISEASE Visit: Blood will be collected at the Baseline visit that will be sent to the National Cell Repository for AD. After completing the information on the two BLD ACD tube bar code labels, as described below, secure one label onto each of two yellow top tubes. Collection Tube: Two 8.5 cc Yellow Top tubes; fill each bar code labeled tube with blood and gently mix by inversion 6-10 times to assure complete mixing of the blood sample with the anticoagulant Acid Citrate Dextrose. Temperature requirements: The whole blood sample must be received by the National Cell Repository within 24 hrs of collection. The whole blood sample is maintained at room temperature and shipped at room temperature.

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