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C2/CFB Complement Genes in progression and severity of Age-Related Macular Degeneration (AMD)

C2/CFB Complement Genes in progression and severity of Age-Related Macular Degeneration (AMD). Brooke Longville Supervised by Lyle Palmer Ian Constable Wayne Greene. What is a Macula?. What is AMD?. Why is AMD Important?. Our Aims and Why we chose C2/CFB. Methods- Population.

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C2/CFB Complement Genes in progression and severity of Age-Related Macular Degeneration (AMD)

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  1. C2/CFB Complement Genes in progression and severity of Age-Related Macular Degeneration (AMD) Brooke Longville Supervised by Lyle Palmer Ian Constable Wayne Greene

  2. What is a Macula?

  3. What is AMD?

  4. Why is AMD Important?

  5. Our Aims and Why we chose C2/CFB

  6. Methods- Population 1013 AMD cases 267 “Early” AMD 746 “Late” AMD 71 Atrophic AMD 675 Neovascular AMD

  7. Methods- Data • Genotypic data- 19 haplotype-tagging Single Nucleotide Polymorphisms (SNPS) across the adjacent C2/CFB genes • Phenotypic Data • Disease phenotypes • Environmental factors and medical history • Visual acuity measurements • Basic demographics

  8. Methods- Analytical • Univariate and Multivariate statistical analysis of various subphenotypic outcomes • Stepwise regression to construct biologically sensible multivariate models • Binary, ordinal, norminal logistic and linear regressions • Sensitivity Ttsted to check for population stratification • Adjusted for multiple testing

  9. Results

  10. Discussion

  11. Summary/Conclusions

  12. Implications of this Research and Future Directions

  13. Acknowledgements

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