140 likes | 242 Vues
Explore the impact of C2/CFB genes on the progression and severity of Age-Related Macular Degeneration (AMD). This study examines the importance of AMD, the genetic and environmental factors involved, and provides insights for future research directions.
E N D
C2/CFB Complement Genes in progression and severity of Age-Related Macular Degeneration (AMD) Brooke Longville Supervised by Lyle Palmer Ian Constable Wayne Greene
Methods- Population 1013 AMD cases 267 “Early” AMD 746 “Late” AMD 71 Atrophic AMD 675 Neovascular AMD
Methods- Data • Genotypic data- 19 haplotype-tagging Single Nucleotide Polymorphisms (SNPS) across the adjacent C2/CFB genes • Phenotypic Data • Disease phenotypes • Environmental factors and medical history • Visual acuity measurements • Basic demographics
Methods- Analytical • Univariate and Multivariate statistical analysis of various subphenotypic outcomes • Stepwise regression to construct biologically sensible multivariate models • Binary, ordinal, norminal logistic and linear regressions • Sensitivity Ttsted to check for population stratification • Adjusted for multiple testing