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Feline Nasal Lymphoma

Feline Nasal Lymphoma. Christina Copple, DVM 4/25/2011 Acc #’s : 148799 148796 ,, 149941. Squeaker, 5yr FS DSH. 6 mths upper respiratory tract infection Initially – excessive sneezing with no discharge, stertor

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Feline Nasal Lymphoma

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  1. Feline Nasal Lymphoma Christina Copple, DVM 4/25/2011 Acc #’s: 148799 148796,, 149941

  2. Squeaker, 5yr FS DSH • 6 mths upper respiratory tract infection • Initially – excessive sneezing with no discharge, stertor • Progressed to serous ocular discharge OS with left mucoid, grey-green, sometimes bloody nasal discharge that • Progressive increase in exudative nasal discharge • No response to Abs, steroids or diphenydramine • Labored breathing & stertorous esp. when eating/drinking

  3. Physical Exam • PE: • Dried serous discharge OS • No air flow from either nares • Green-yellow, bubbly nasal discharge, left • Slightly prominent mandibular LNs, bilateral • Felv/FIV per RDVM

  4. Diagnostic Imaging • Thoracic Radiographs: no evidence of metastatic disease, mild inflammatory airway disease • Abdominal US: no evidence of metastatic disease, mild bilateral renal degenerative changes • CT scan of nose • Rhinoscopy

  5. CT Scan of Nose R R L L

  6. CT Scan of Nose R R L L

  7. CT Scan of Nose

  8. Rhinoscopy

  9. Biopsy of nasal mass • Round cell neoplasia – consistent with lymphoma VetPath (2007) 44, 885-892

  10. Feline LSA • Most common feline neoplasia: 33% of all tumors • Classic form – lympho-reticular system • Abdominal & atypical forms: 20-50% of reported cases • Extranodal LSA: atypical or miscellaneous • Atypical = renal, nasal/paranasal, CNS, ocular, laryngeal, cutaneous • Nasal LSA – most common nasal tumor in cats JSAP (2009) 50, 584-592 VetPath (2007) 44, 885-892

  11. Feline Nasal LSA • Most frequent form of extranodal LSA in 69/149 – 46.3% • Duration of clinical signs longer • Frequent clinical signs at presentation • Nasal discharge – mostly purulent • Epistaxis • Sneezing • Stridor or stertor • Facial deformity JSAP (2009) 50, 584-592 VetPath (2007) 44, 885-892

  12. Feline Sinonasal LSA • Nasal LSA more common than nasopharyngeal • B-cell type predominates (regardless of site) • May locally extend into CNS • May have multiorgan involvement VetPath (200) 44, 885-892

  13. Feline Nasal LSA: CT findings • Soft tissue, contrast enhancing mass • Mass often associated with extensive lysis of nasal bone and turbinates • Septal deviation • Sinus fluid JSAP (2009) 50, 584-592 VetPath (2007) 44, 885-892

  14. Squeaker - outcome • More local disease, confined to nasal cavity  local radiation therapy of choice • Definitive radiation therapy

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