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Lysozyme

Lysozyme. http://en.wikipedia.org/wiki/Lysozyme. A.k.a : Muramidase OR N-acetylmuramide glycanhydrolase. Lysozyme. An enzyme found naturally in • egg white • human tears • saliva (as well as other body fluids) Capable of destroying the cell walls of certain bacteria.

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Lysozyme

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  1. Lysozyme http://en.wikipedia.org/wiki/Lysozyme A.k.a : Muramidase OR N-acetylmuramide glycanhydrolase

  2. Lysozyme An enzyme found naturally in • egg white • human tears • saliva (as well as other body fluids) Capable of destroying the cell walls of certain bacteria. Acts as a mild antiseptic.

  3. Amino Sequence Fig 5. Lysozyme amino acid sequence alignment for five organisms (Dmelanogaste-fly, EcoligsnAA-E. coli, GgallusgsnAA-chicken, HsapiensgsnA-human, and Mmusculusgsn-mouse). Number to the left and right of the sequences and above each sequence group indicate amino acid number. Letters represent amino acids, with dashes (-) inserted to maximize sequence alignment. Black boxes indicate amino acid conservation.

  4. Made with 117 amino acid residues and has a heterogeneous sequence. Structure <http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1rem#> 1REM 133L 1IWV Quaternary Structure (4°)

  5. Function Lysozyme attacks peptidoglycans and hydrolyzes the glycosidic bond that connects N-acetylmuramic acid with the fourth carbon atom of N-acetylglucosamine. It does this by binding to the peptidoglycan molecule in the binding site within the prominent cleft between its two domains. Peptidoglycans- sugars & amino acids that form a mesh-like layer outside the plasma membrane of bacteria, forming the cell wall. Hydrolysis- Decomposition of a chemical compound by reaction with water, such as the dissociation of a dissolved salt or the catalytic conversion of starch to glucose. http://en.wikipedia.org/wiki/Lysozyme

  6. Present in other Organisms • bacteriophages (viruses that infect bacteria) • bacteria • plants • animals

  7. Misc… • Lysozyme was first identified and named by Alexander Fleming, who recognized its bacteriolytic properties. (1922) • Bottlefed babies are 3 times likely to have diarrheal disease, because they lack lysozyme in their diet... [its in breast milk!] Lysozyme is a natural form of protection from pathogens. Bacteriolysis -destruction or dissolution of bacterial cells

  8. Works Cited: • Yikrazuul. "Lysozyme." Wikipedia. N.p., 14 Oct. 2009. Web. 14 Oct. 2009. <http://en.wikipedia.org/ wiki/Lysozyme>. • Muraki, M., et al. "HUMAN LYSOZYME WITH MAN-B1,4-GLCNAC COVALENTLY ATTACHED TO ASP53." RCSB Protein Data Bank. N.p., 14 Oct. 2009. Web. 14 Oct. 2009. <http://www.rcsb.org/pdb/cgi/ explore.cgi?pdbId=1rem>. 3. Secretlens. "Drool." DeviantArt. N.p., 15 July 2009. Web. 14 Oct. 2009. <http://secretlens.deviantart.com/art/Drool-129635147>. 4. funkipunk . “Tears Speak." DeviantArt. N.p., 13 Nov. 2007. Web. 14 Oct. 2009. <http://funkipunk.deviantart.com/art/Tears-Speak-69773894>. 5. Caothicart . “Dark Pikachu." DeviantArt. N.p., 10 June 2007. Web. 14 Oct. 2009. <http://caothicart.deviantart.com/art/Dark-Pikachu-57318376>. • Chueh, Luke . “I ASKED FOR SCRAMBLED.” LukeChueh N.p., 2003. Web. 14 Oct. 2009. <http://www.lukechueh.com/paintings/i-asked-for-scrambled.html>. • Stryer L. 1995. Biochemistry. 4th ed. New York: W.H. Freeman and Company. p 372. • "MacDNAsis Analysis of Lysozyme Genbank search results." Davidson College. N.p., 30 Nov. 2001. Web. 14 Oct. 2009. <http://www.bio.davidson.edu/Courses/Molbio/MolStudents/01grnoland/ MacDNAsis.html>.

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