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Topic. Proposed project: neutrotoxin Fasciulin Found in snakes such as the Green and Black Mamba. Explanation. Fasciculin is known to inhibit reversibly mammalian and fish acetylcholinesterases at picomolar concentrations. What is a toxin? Find more about acetylcholinesterases .

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  1. Topic • Proposed project: neutrotoxinFasciulin • Found in snakes such as the Green and Black Mamba.

  2. Explanation • Fasciculin is known to inhibit reversibly mammalian and fish acetylcholinesterases at picomolar concentrations. • What is a toxin? • Find more about acetylcholinesterases. • Look in reversible inhibitors. • Should indicate functional groups. • Structural information • Fasciculin-II (FAS-II) is a 61-residue polypeptide, three fingered toxin purified from green mamba venom. • What is a three fingered toxin? • How do these disulfides work in this neurotoxin?

  3. Needed Background Information • Examine function of acetylchoine. • Need to understand more at the molecular level. • How would an antivenom work for this neurotoxin at the molecular level? • How does fasciclininterfer with the normal binding process of acetylcholinesterase (AChE)? What does it change?

  4. Why? • Give explanation of what made you interested in the project? • Heard an explanation of this toxin in Kill Bill Volume 2.

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