Understanding Osteoporosis: Causes, Detection, and Treatment Options
Osteoporosis is a condition characterized by weakened bones, leading to a higher risk of fractures. It is essential to understand the skeletal system, including bone anatomy and histology, as well as age-related changes that affect bone and cartilage. Detection methods, such as Dual Energy X-Ray Absorptiometry (DXA), measure bone mineral density and assess fracture risk. FDA-approved treatments include bisphosphonates, calcitonin, and hormone therapies. Preventive measures and lifestyle changes are critical in maintaining bone health, particularly for postmenopausal women.
Understanding Osteoporosis: Causes, Detection, and Treatment Options
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Presentation Transcript
1. Skeletal System
2. Anatomy of Bone
3. Histology of Bone
4. Haversian System
5. Cartilage
6. Age Related Changes (Cartilage)
7. Age Related Changes (Bone)
8. Age Related Dysfunctions
9. Osteoarthritis
10. Arthritis (cont.)
11. Osteoporosis
12. Osteoporosis
13. Detection Specialized test (Dual Energy X-Ray Absorptiometry or DXA) can measure bone mineral density (BMD) in various sites of the body. A BMD test can:
Detect osteoporosis before a fracture occurs
Predict chances of fracturing in the future
Determine rate of bone loss and/or monitor the effects of treatment if a DXA BMD test is conducted at intervals of one year or more
14. Treatment The following medications are approved by the FDA for postmenopausal women to prevent and/or treat osteoporosis:
Bisphosphonates (inhibit bone resorption)
Alendronate and alendronate plus vitamin D (brand name Fosamax® and Fosamax® plus D)
Ibandronate (brand name Boniva®)
Risedronate and risedronate with calcium (brand name Actonel® and Actonel® with Calcium)
Calcitonin (brand name Miacalcin®)
Estrogen/Hormone Therapy
Estrogens (brand names, such as Climara®, Estrace®, Estraderm®, Estratab®, Ogen®, Ortho-Est®, Premarin®, Vivelle® and others)
Estrogens and Progestins (brand names, such as Activella™, FemHrt®, Premphase®, Prempro® and others)
Selective Estrogen Receptor Modulators (SERMs)
Raloxifene (brand name Evista®)
15. Prevention