'Disulfide bonds' diaporamas de présentation

Reductive denaturation and oxidative renaturation of RNase A

Reductive denaturation and oxidative renaturation of RNase A. Plausible mechanism for the thiol- or enzyme-catalyzed disulfide interchange reaction in a protein. protein disulfide isomerase. C-chain needed to direct proper disulfide bond formation. Primary structure of porcine proinsulin.

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Amino Acids General

Amino Acids General. Amino Acids: Building blocks for peptides, proteins Some individually important (or converted to important molecules) Gly , Glu , Tyr ? neurotransmitters Tyr ? parent/precursor for epinephrine (adrenaline)

732 views • 60 slides

1.2 CARBOHYDRATES

1.2 CARBOHYDRATES. 1.1 WATER . 1.3 LIPIDS . MOLECULES OF LIFE. 1.5 NUCLEIC ACIDS . 1.4 PROTEINS . 1.4 PROTEINS. 1.4 Proteins (2 hours). Objectives : Describe the basic structure of amino acids. Describe the classes of amino acids and explain how they are grouped.

1.18k views • 55 slides

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??? ???? ?????? ??????. Faculty of Allied Medical Sciences Clinical Immunology & Serology Practice (MLIS 201). IMMUNOLOGY SEROLOGY. Over View. Prof. Dr. Ezzat M Hassan Prof. of Immunology Med Res Inst, Alex Univ E-mail: elgreatlyem@hotmail.com.

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PROTEIN STRUCTURE AND FUNCTION

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Lecture 5

Lecture 5. Peptides : Primary sequence and experimental techniques. Peptide Bond. Peptide Bond Formation. Activated Intermediates. Naming Peptides. Levels of Protein Structure. Primary structure: Determination of sequence. Protein Homology. BLOSUM60 Matrix.

543 views • 33 slides

Proteins Structures

Proteins Structures. Primary Structure . Proteins. Primary Structure . Proteins. Sequence of Amino Acids . Proteins. Primary Structure . Proteins. Secondary Structure - Alpha Helix. Secondary Structure of Proteins. Alpha Helix - hydrogen bonds between amide groups.

1.46k views • 29 slides

Amino Acids, Peptides, Proteins

Amino Acids, Peptides, Proteins. Functions of proteins: Enzymes Transport and Storage Motion, muscle contraction Hormones Mechanical support Immune protection (Antibodies) Generate and transmit nerve impulses Control growth and differentiation Lens protein in eye Feathers Spider webs

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Amino Acids and the Primary Structure of Proteins

Amino Acids and the Primary Structure of Proteins. Important biological functions of proteins 1. Enzymes, the biochemical catalysts 2. Storage and transport of biochemical molecules 3. Physical cell support and shape (tubulin, actin, collagen)

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Limited Proteolysis

Limited Proteolysis. Kyle Arrington , Syna Daudfar, Shiana Ferng , Tyler Foutch , Jay Mitchell, Siddharth Pandya, and Arvin Jandu Fall 2011 - BIOC463A. Test the effects of DTT on the stability of Alkaline Phosphatase (AP) during tryptic digestion. Purpose. AP is very stable

574 views • 14 slides

Chapter 20 Amino Acids and Proteins

Chapter 20 Amino Acids and Proteins. 20.6 Protein Structure: Tertiary and Quaternary Structure 20.7 Protein Hydrolysis and Denaturation. Tertiary Structure. The tertiary structure : Gives a specific overall shape to a protein.

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14.5 Uncommon Amino Acids

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7.4/14.1 PROTEINS

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Post-Translational Modification 1. Dealing with the N-terminal residue

Posttranslational modification is the chemical modification of a protein after its translation. Proteins often undergo several post-translational modification steps in parallel to protein folding. These modifications can be transient or permanent.

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Antibodies ( Immunglobulins ( Igs ) A- Definition:

Antibodies ( Immunglobulins ( Igs ) A- Definition: Immunoglobulins are a group of proteins (gamma globulins) produced by the body from B lymphocytes and plasma cells in response to presence of foreign bodies (antigens). There are 5 basic types: G, M, A, E and D.

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Ch 12 Alcohol & Thiol

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Grammatical inference for disulfide bonds prediction within proteins

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Disulfide bonds prediction using ILP

Abstract

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One-pot total synthesis of K1 HGF domain

S. S. a chain. b chain. Hepatocyte growth factor 90 kD. N. K1. K2. K3. K4. 85 Aa. 3 disulfide bridges. K1 weak MET Tyrosine kinase receptor agonist (Holmes, O. J. Mol. Biol. 2007 , 367 , 395) Part of HGF high affinity binding site. One-pot total synthesis of K1 HGF domain.

135 views • 1 slides

96 Aa

Crude one-pot assembly. Reduced N protein. PDB : 1BHT, Ultsch, M. Structure 1998 , 6 , 1383-1393. Folding 1 h. Folding 24 h. One-pot total synthesis of N HGF domain. S. S. a chain. b chain. Hepatocyte growth factor 90 kD. N. K1. K2. K3. K4. HPLC purified.

152 views • 1 slides