'Interval mapping' diaporamas de présentation

Fei Zou Department of Biostatistics Email: fzou@bios.unc

Bayesian Variable Selection in Semiparametric Regression Modeling with Applications to Genetic Mappping. Fei Zou Department of Biostatistics Email: fzou@bios.unc.edu. Outline. Introduction Experimental crosses Existing QTL Mapping Methods Bayesian semi-parametric QTL Mapping Results

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Statistical Methods for Quantitative Trait Loci (QTL) Mapping II

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QTL mapping in mice, completed.

QTL mapping in mice, completed. Lecture 12, Statistics 246 March 2, 2004. REVIEW. n backcross mice; M markers in all, with at most a handful expected to be near QTL x ij = genotype (0/1) of mouse i at marker j y i = phenotype (trait value) of mouse i

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Lecture 6: QTL Mapping

Lecture 6: QTL Mapping. P 1 x P 2. B 2. B 1. F 1. F 1. F 1 x F 1. F 1. F 1. Backcross design. Backcross design. F 2 design. F 2. F 2. Advanced intercross Design (AIC, AIC k ). F k. Experimental Design: Crosses. Experimental Designs: Marker Analysis. Single marker analysis.

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Statistical Methods for Quantitative Trait Loci (QTL) Mapping

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Statistical Methods for Quantitative Trait Loci (QTL) Mapping

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X ia - genotype of i-th individual at locus a X ia = 1/2 - individual is heterozygous at locus a

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Presented by: Yan Wang

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Lecture 14 - Complex Traits and QTL Maping

Lecture 14 - Complex Traits and QTL Maping. Doerge (2001) Nature Genetics Reviews 3:43-52 Neale, chapter 18 Liu, chapters 13-14. Figures from Lander and Schork , Science, 265-September 1994-pp2037. QTL Mapping. Mapping population Markers and a map Phenotypes (trait measurements)

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What is a QTL?

What is a QTL?. What are QTL?. Current methods for QTL. Single Marker Methods ( Student, 17?? ) t-tests Interval Mapping Method (Lander and Botstein, Genetics 1989) Mapping: estimate genetic maps Locating QTL: based on genetic map

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QTL mapping

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Human Quantitative Traits

Human Quantitative Traits. By: Eric Pacynski Tyler Tsagalis. What is it?. Human Quantitative traits are phenotypes that can vary and can be attributed to polygenic effects like the product of two genes or environment. Basically, a phenotype influenced by multiple genes.

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Composite interval mapping Significance thresholds Confidence intervals Experimental design

Composite interval mapping Significance thresholds Confidence intervals Experimental design. Association between genotype and phenotype. Interval mapping vs. Composite interval mapping. Interval mapping

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- Type of Study

Composite Interval Mapping Program. - Type of Study. - Genetic Design. Composite Interval Mapping Program. - Data and Options. Cumulative Marker Distance (cM). Map Function. QTL Searching Step. cM. Parameters Here for Simulation Study Only. Composite Interval Mapping Program. - Data.

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Lecture 7: QTL Mapping I: Inbred Line Crosses

Lecture 7: QTL Mapping I: Inbred Line Crosses. P 1 x P 2. B 2. B 1. F 1. F 1. F 1 x F 1. F 1. F 1. Backcross design. Backcross design. F 2 design. F 2. F 2. Advanced intercross Design (AIC, AIC k ). F k. Experimental Design: Crosses. Experimental Designs: Marker Analysis.

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Interval Mapping

Interval Mapping. Interval Mapping Program. - Type of Study. - Genetic Design. Interval Mapping Program. - Data and Options. Names of Markers: (Optional). Map Function. QTL Searching Step. cM. Parameters Here for Simulation Study Only. Interval Mapping Program. - Data.

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QZZ

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Class 4

Class 4. Interval mapping EM algorithm http://aass.oru.se/~tdt/ml/extra-readings/EM_algorithm.pdf http://ssli.ee.washington.edu/people/bulyko/papers/em.pdf.

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