'Lod score' diaporamas de présentation

Introduction to linkage analysis

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Linkage and Association

Linkage and Association. John P. Rice, Ph.D. Washington University School of Medicine. Outline. Linkage Linkage Disequilibrium Haplotypes History of GWAS dbGaP Methods Genomic Inflation Factor False Discovery Rate Ethnic Stratification QQ-Plots. Definition of centimorgan (cM).

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Searching Microsatellite Markers for Mapping a Disease Gene

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Linkage Analysis

Linkage Analysis. Eric Jorgenson Epidemiology 217 2/26/13. Worldwide Distribution of Human Earwax SNP rs17822931. Yoshiura et al., Nature Genetics 2006. Geographic Distribution of PTC Phenotype. High. Low. Wooding Genetics 2006, adapted from Cavalli-Sforza 1994.

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Linkage Analysis

Linkage Analysis. Eric Jorgenson EPI 217 1/25/11. More taste strips. One long One short. Bimodal Distribution of PTC. Types of Genetic Studies. Family Studies Compare trait values across family members Linkage Analysis Compare trait values with inheritance patterns Association

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GENOME MAPPING

GENOME MAPPING. Ms.ruchi yadav lecturer amity institute of biotechnology amity university lucknow (up). GENOME MAPPING. GENETIC MAPPING PHYSICAL MAPPING. GENOME MAPPING.

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LEZIONE 3 Anno Accademico 2010/11

BIOTECNOLOGIE FARMACOLOGICHE CORSO DI LAUREA SPECIALISTICA IN BIOTECNOLOGIE DEL FARMACO. LEZIONE 3 Anno Accademico 2010/11. Mappare i geni : Storicamente attraverso la costruzione di mappe fisiche (identificare e ordinare marcatori lungo il cromosoma) Attualmente con il sequenziamento.

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HOMOZYGOSITY MAPPING USING LOD SCORE METHOD

HOMOZYGOSITY MAPPING USING LOD SCORE METHOD. BBS- 6. CONTENTS. INTRODUCTION METHODS OF HOMOZYGOSITY MAPPING HOMOZYGOSITY MAPPER GENETIC LINKAGE LOD SCORE METHOD. LET US START WITH THE BASICS!. KEY TERMS. HOMOZYGOSITY. Containing two identical allelic forms Can be homozygous dominant

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Gene mapping in model organisms

Gene mapping in model organisms. Goal. Identify genes that contribute to common human diseases. Inbred mice. Advantages of the mouse. Small and cheap Inbred lines Large, controlled crosses Experimental interventions Knock-outs and knock-ins. The mouse as a model. Same genes?

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LINKAGE ANALYSIS

LINKAGE ANALYSIS. Recombination Fraction. During synapsis , crossing-over may occur between any two non-sister chromatids If there are allelic differences at the site of crossing over, the genetic result is recombination Genes on the same chromosome are connected physically (syntenic)

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Gene mapping in mice

Gene mapping in mice. Karl W Broman Department of Biostatistics Johns Hopkins University http://www.biostat.jhsph.edu/~kbroman. Goal. Identify genes that contribute to common human diseases. Inbred mice. Advantages of the mouse. Small and cheap Inbred lines Large, controlled crosses

780 views • 45 slides

Strategies for investigating the genetics of psychiatric disorders

Strategies for investigating the genetics of psychiatric disorders. Margit Burmeister, Ph.D. Molecular & Behavioral Neuroscience Institute (formerly Mental Health Research Institute) Department of Psychiatry Department of Human Genetics Neuroscience Program Bioinformatics Program

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Strategies for investigating the genetics of psychiatric disorders

Strategies for investigating the genetics of psychiatric disorders. Margit Burmeister, Ph.D. Molecular & Behavioral Neuroscience Institute (formerly Mental Health Research Institute) Department of Psychiatry Department of Human Genetics Neuroscience Program Bioinformatics Program

457 views • 37 slides

Introduction to QTL mapping

Introduction to QTL mapping. Manuel Ferreira. Boulder Introductory Course 2006. Outline. 1. Aim. 2. The Human Genome. 3. Principles of Linkage Analysis. 4. Parametric Linkage Analysis. 5. Nonparametric Linkage Analysis. 1. Aim. QTL mapping.

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Linkage and LOD score

Linkage and LOD score. Manuel AR Ferreira. Massachusetts General Hospital. Harvard Medical School. Boston. Egmond, 2006. Outline. 1. Aim. 2. The Human Genome. 3. Principles of Linkage Analysis. 4. Parametric Linkage Analysis. Practical. 5. Nonparametric Linkage Analysis. 1. Aim.

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Statistical Methods for Quantitative Trait Loci (QTL) Mapping II

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Advanced Algorithms and Models for Computational Biology -- a machine learning approach

Advanced Algorithms and Models for Computational Biology -- a machine learning approach. Population Genetics: Quantitative Trait Locus (QTL) Mapping Eric Xing Lecture 17, March 22, 2006. Reading: DTW book, Chap 13. Phenotypical Traits. Body measures:

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QTL mapping in mice

QTL mapping in mice. Lecture 10, Statistics 246 February 24, 2004. The mouse as a model. Same genes? The genes involved in a phenotype in the mouse may also be involved in similar phenotypes in the human. Similar complexity?

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Mapping genes with LOD score method

Mapping genes with LOD score method. LOD score method. Aim: Determine ? , the recombinant fraction (fraction of gametes that are recombinant), using data from relatively small families. Reminder: ? vary from 0 (2 genes completely linked) to 0.5 (2 genes are unlinked).

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BIO 304 Review for final exam

BIO 304 Review for final exam. http:// tmblr.co / ZUrBwxC-ohpJ. Overall organization of exam. 30 multiple choice questions @ 2.5 points each = 75 points 16 fill-in-the-blank questions @ 2.5 points each = 40 points 6 problems @ 10 points each = 60 points

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