'Myeloproliferative disorders' diaporamas de présentation

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??? ???? ?????? ??????. Leukocytes. Leukopenia Leukocytosis. Leukopenia (Agranulocytosis). Myeloid stem cell suppression Ineffective granulopoisis Heriditary disorders, kostmann syn. Immune destruction Spleenic sequestration Peripheral destruction. Leukocytosis. Normal Lymph node.

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Lecture 6 and 7

Lecture 6 and 7 Myelodysplastic syndromes; Chronic l ymphocytic leukemia and related lymphoproliferative disorders Abdulkarim Aldosari. O bjectives. Describe the etiology, pathogenesis, clinical features and treatment of MDS Describe laboratory diagnosis of MDS

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Lecture 6 and 7

Lecture 6 and 7 Myelodysplastic syndromes; Chronic l ymphocytic leukemia and related lymphoproliferative disorders Abdulkarim Aldosari. O bjectives. Describe the etiology, pathogenesis, clinical features and treatment of MDS Describe laboratory diagnosis of MDS

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Pathology Course Haematology 2

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The Circulatory System

The Circulatory System. Cardiovascular and Lymphatic systems combined Incorporates lymphomas and leukaemias Both systems and diseases involve blood production sites Bone marrow, spleen, lymph nodes etc. BLOOD. 45% formed elements Erythrocytes Leucocytes Thrombocytes . 55% Plasma Water

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HEMATOLOCICAL CLONAL DISORDERS (MALIGNANCIES)

HEMATOLOCICAL CLONAL DISORDERS (MALIGNANCIES). LYMPHO- PROLIFERATIVE DISORDERS. MYELOID DISORDERS. MYELO- APLASTIC (?). MYELO- DISPLASTIC. MYELO- PROLIFERATIVE. MOLECULAR PATHS TO CANCER I. PROLIFERATION. APOPTOSIS. DIFFERENTIATION. Neoplasie della linea mieloide.

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PULMONARY HYPERTENSION

PULMONARY HYPERTENSION. ADIL K. WARSY M.D. PGYV PULMONARY FELLOW. FINANCIAL DISCLOSURES. None. OBJECTIVES. Learn to define the disorder Classification and prevalence Pathophysiology and histopathology Presentation Screening and diagnostic methods Functional classification

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THE PARADOXICAL RBC

THE PARADOXICAL RBC. MEDICINE GRANDROUNDS December 2, 2010 Presented by: Suzanne V. Santos, M.D. Moderator: Jesus A. Relos, M.D., FPCP. Objectives. 1. To discuss the diagnostic approach in a patient presenting with erythrocytosis and thrombocytosis.

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Senior Academic Half Day: Malignant Haematology

Senior Academic Half Day: Malignant Haematology. Beth Harrison Department of Haematology University Hospitals Coventry and Warwickshire NHS Trust. Normal haematopoiesis Investigations in malignant haematology Approach to a patient with pancytopenia Diagnosis and management. Case 1.

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An Ongoing Story of Discovery: Pathophysiology of Chronic Myeloproliferative Disorders

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MYELOPROLIFERATIVE DISORDERS EVOLVING CONCEPTS

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PLATELET DISORDERS

PLATELET DISORDERS. Joanna Rupa-Matysek. Hemostatic System - general information. Normal hemostatic system vessel wall circulating blood platelets blood coagulation and fibrynolysis. Bleeding Diathesis. inherited or acquired defects of vessel wall platelets number and/or function

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Frequent (and less frequent) Skin Conditions in Elderly

Frequent (and less frequent) Skin Conditions in Elderly. Rozenman Dganit Dermatology Department Haemek Medical Center. Pruritus. The most common complaint of the elderly. DEFINITION. Pruritus , or itch, is defined as an unpleasant sensation that provokes the desire to scratch. Frequency :.

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HAEMOSTASIS

HAEMOSTASIS. Definition. Haemostasis is a complex sequence of physical and biochemical changes induced by damage to tissues and blood vessels, which transform the blood into a clot, and, later, bring about the repair of damaged vascular endothelium. Fundamental Steps in Haemostasis.

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Hypercoagulable States: Polycythemia Vera

Hypercoagulable States: Polycythemia Vera. Chris Caulfield AM Report Oct 20, 2009. Inherited: Factor V Leiden mutation Prothrombin gene mutation Protein S deficiency Protein C deficiency Antithrombin III deficiency Hyperhomocysteinemia. Acquired: Malignancy Surgery/Trauma Pregnancy

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Hypercoagulable States: Polycythemia Vera

Hypercoagulable States: Polycythemia Vera. Chris Caulfield AM Report Oct 20, 2009. Inherited: Factor V Leiden mutation Prothrombin gene mutation Protein S deficiency Protein C deficiency Antithrombin III deficiency Hyperhomocysteinemia. Acquired: Malignancy Surgery/Trauma Pregnancy

544 views • 17 slides

STEM CELL

STEM CELL. Four types EMBRYONIC STEM CELLS ADULT STEM CELLS PLACENTAL STEM CELLS (Cord Blood Stem Cells). Amniotic fluid Stem cells. Three general properties: they are capable of dividing themselves for long periods; they are unspecialized; and

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Chronic Myeloid Leukemia

Chronic Myeloid Leukemia. Leukemia. ALL, AML, CLL Chronic Myelogenous Leukemia Cancer of the granulocytes or monocytes, compared to leukocytes in lymphocytic leukemias Comprises about 14% of all adult leukemias Males slightly higher than females

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PDGF Receptor Beta & Chronic Myelenomonocitic Leukemia

PDGF Receptor Beta & Chronic Myelenomonocitic Leukemia. PDGFR-B is a receptor tyrosine kinase and is distinct from PDGFR-A. PDGF signaling activates a number of key pathways in the cell. PDGFRB null mutants showed abnormal kidney development and hematological disorders.

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Hematopoietic stem cell

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