'Peptide' diaporamas de présentation

Antigens and “foreignness”. Antigens (or, more properly, immunogens ) have a series of features which confer immunogenicity. One of these features is “foreignness.” So, we can infer that – most often – antigens – ultimately – originate externally.

Ligand Docking to MHC Class I Molecules . Lam Tze Hau. Major Histocompatibility Complex (MHC) Class I. Play a vital role in the adaptive immune response. Generate maximal immunological protection against a large repertoire of pathogens.

Identifying Hidden Free Energy Barriers. Chris Neale , Angel García , Régis Pomès. Rensselaer Polytechnic Institute. Creative Commons (Mariana Ruiz). Creative Commons ( Asd.and.Rizzo ). Vertex Pharmaceuticals, Boston 2014 Workshop on Free Energy Methods in Drug Design. x34,000.

Each results report will contain: C hromatogram for sample All proteins identified with probability <1.0 List of peptides identified for each protein Amino acid coverage of each protein identified. Example of a chromatogram (peptide with 12.6 min retention time highlighted in red ).

Chapter 16. Endocrine System. BIOL242. Overview. Endocrine system functions Endocrine vs. neural control Types of hormones and their receptors Hypothalamic – pituitary regulation Anterior pituitary Specific endocrine organs Endocrine diseases. Two types of glands in the body.

Proteomics Informatics – Protein identification II: search engines and protein sequence databases  (Week 5). General Criteria for a Good Protein Identification Algorithms. The response to random input data should be random.

The endocrine system. Honors Anatomy & Physiology. Endocrine vs nervous system. act together to coordinate body’s activities both: use chemical messengers to communicate cell to cell major function: homeostasis endocrine : slower response time

Molecular modeling activities. Computational MAterials Science and Technology Lab CMAST Laboratory : www.afs.enea.it/project/ cmast. Caterina Arcangeli UTTMAT-DIAG Francesco Buonocore UTTMAT-SUP Massimo Celino UTTMAT-DIAG Roberto Grena UTTRIN-PCI

Bovine Reproductive Physiology and Endocrinology . By C. Kohn, Waterford, WI. Hormones 101. An animal’s body must have consistency – a body’s physiological variables must be kept within a narrow range

Levels of Protein Structure 16.5. Peptide/Protein Formation. Peptide: small, up to 50 AA Proteins: large, several 100 AA and/or multiple peptide chains grouped together Ribosomes translates m-RNA into AA sequence: 3 nucleotide = 1 AA. 1 o Primary Structure. Number and order of AA

vFLIP-IKK g Blocker . Edith Chan WIBR. IKK g. NF- k B Pathway. The Nf- k B pathway is related to inflammatory responses, cell death, and oncogenesis. Kaposi’s sarcoma herpesvirus (KSHV) encoded FLIP (vFLIP) binds to IKK g to activate NF k B.

THE GILA MONSTER. THE GILA MONSTER. A very sluggish animal. Inactive from mid -November to early March. Active about 30% of the time during the hot wet season. How can it be so inactive ?. Yummy ! A hamster !. But why is it so interesting ?. Toxicity of the venom. IMMUNE.

Prolactin in Mammals. By: Megan the epic M, Erica the fried squid pickel , Abby, Alyssa, Katie, Hiba. Gland. Prolactin is produced in the pituitary gland in response to pregnancy and nursing. Base. Peptide-based It is a pituitary polypeptide Alpha helix folded. Pathway/Mechanism.

Reminders. Exam 2: Wed, Feb 20: Cytokines Ch 2 & 4 Antibody function- part of chapter 2 will not be on this exam. . WALKER BIOLOGY CLUB MEETING & GUEST SPEAKER!!. Dr. Larry Grand from N.C. State’s Plant Pathology Department will be speaking!

Self-assembly of Peptide Nanotubes NSF Site Visit June 10, 2004 Shuguang Zhang Center for Biomedical Engineering, Center for Bits & Atoms Massachusetts Institute of Technology Cambridge, MA 02139, USA. Peptide surfactant-detergents. Sylvain Vauthey, PNAS , 4/2002,

As-Deposited Carbon. After 3 hrs in 5µM GrBP2. Height (10 nm). 40 µm 2. 20 µm 2. As-Is Carbon on Si, no peptide. 500 nm 2. Height (5nm). Amplitude (0.10V). Phase (45°). Height (5nm). 25 µm 2. Amplitude (0.1V ). 2 µm 2. Phase (45°). As-Is Carbon After 3 hrs in 5µM GrBP2. 500 nm 2.

Development. ab T lymphocyte Development. Where do T cells come from?. 1. Multipotent Lymphoid Progenitors Migrate from the Bone Marrow to the Thymus. 2. In the Thymus, the Lymphoid Progenitors Differentiate to pre-T Cells and are Educated to Differentiate Self from Non-self.

HLA Genetics. Different MHC alleles confer different functional properties on the adaptive immune system. Polymorphic residues of MHC. Each different allelic MHC molecule (allotype) confers the ability to bind different peptides. Consequences for regulation of adaptive immunity:.

B. F/F 0  500. C. D. K d  1 µM. K d  0. 1 µM. Fraction dCaM bound. Fraction dCaM bound. 1 mM EGTA 50 µM free Ca 2+. [Peptide B] (  M). [Peptide E] (µM).