'Population stratification' diaporamas de présentation

Association Studies in Unrelated populations: Perils and Opportunities

Association Studies in Unrelated populations: Perils and Opportunities. Elad Ziv, M.D. Outline. I. Population Structure, Admixture II. Population stratification: Confounding due to population structure/admixture III. Detecting and controlling for stratification

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Bias in Studies of the Human Genome

Bias in Studies of the Human Genome. Thomas A. Pearson, MD, PhD University of Rochester School of Medicine Visiting Scientist, NHGRI. Lecture 6: Bias in Studies of the Human Genome. 1. Consider the causes of heterogeneity of results in gene association studies.

684 views • 50 slides

Control of Population Stratification in Whole-Genome Scans

Control of Population Stratification in Whole-Genome Scans. Fei Zou fzou@bios.unc.edu Department of Biostatistics Carolina Center for Genome Sciences University of North Carolina at Chapel Hill. Outline. Introduction: Genome-wide association study (GWAS) Population Stratification

589 views • 44 slides

Molecular & Genetic Epi 217 Association Studies: Direct

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Peter Kraft pkraft@hsph.harvard Bldg 2 Rm 207 2-4271

EPI293 Design and analysis of gene association studies Winter Term 2008 Lecture 6: Population stratification. Peter Kraft pkraft@hsph.harvard.edu Bldg 2 Rm 207 2-4271. Population stratification.

516 views • 41 slides

PLINK : a toolset for whole genome association analysis

PLINK : a toolset for whole genome association analysis. Shaun Purcell shaun@pngu.mgh.harvard.edu Center for Human Genetic Research, Massachusetts General Hospital Broad Institute of Harvard & MIT. Purcell et al (2007) AJHG. Data management Summary statistics Population stratification

1.21k views • 37 slides

Association mapping: finding genetic variants for common traits & diseases

Association mapping: finding genetic variants for common traits & diseases. Manuel Ferreira. Genetic Epidemiology. Queensland Institute of Medical Research Brisbane. WEHI Postgraduate seminar, 31 May 2010. Why?. Understand disease aetiology.

470 views • 33 slides

Single Nucleotide Polymorphism And Association Studies

Single Nucleotide Polymorphism And Association Studies. Stat 115/215. International HapMap Project. The International HapMap project is a recent, large-scale effort to facilitate GWAS studies: Phase 1: 269 samples, 1.1 M SNPs Phase 2: 270 samples, 3.9 M SNPs

504 views • 31 slides

Single Nucleotide Polymorphism And Association Studies

Single Nucleotide Polymorphism And Association Studies. Stat 115/215. International HapMap Project. The International HapMap project is a recent, large-scale effort to facilitate GWAS studies: Phase 1: 269 samples, 1.1 M SNPs Phase 2: 270 samples, 3.9 M SNPs

462 views • 31 slides

17/01/2008

What is Population Stratification? Heterozygote Advantage? Random Genetic Drift? What is a Founder Effect? Give Examples, Define Penetrance, Expressivity. 17/01/2008. Random Genetic Drift. aka allelic drift

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Define Heterozygote Advantage, Random Genetic Drift and Population Stratification

Define Heterozygote Advantage, Random Genetic Drift and Population Stratification. Alison Skinner RCPath Self Help January 22 nd 2009. Heterozygote Advantage. Heterozygotes have greater relative fitness compared homozygote wildtype and homozygote for the mutation

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Funding opportunities in illicit drugs research in H2020

Funding opportunities in illicit drugs research in H2020. INFO SESSION Lisbon 22 September. Authors: Aziz Naji - BELSPO. FACT. ERANID Statement for the preparation of the work programme 2016/2017 of Horizon 2020:

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Principal Component 1

Ansung. Ansan. Principal Component 2. Principal Component 1. Supplementary Figure 1. Population stratification of Ansung and Ansan . The PCA analysis by using the Affymetrix 5.0 SNP array were conducted by EIGENSTAT.

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polyomx

10 -6. 2 x 10 -5. *. *. 9 x 10 -6. 2 x 10 -3. *. *. 10 -6. *. 4.5 x 10 -3. *. One Locus. Two Locus. Three Locus. Four Locus. Genes. MMP9. BCL2/CYP2D6. XPC/XRCC3/BCL2. XPC/BRCA2/XRCC3/BCL2. SNPs. rs2250889. rs1811018 rs1800071r. Rs2228001 rs861539/1801018.

179 views • 1 slides