'Stat3' diaporamas de présentation

Rearrangements and Duplications in Tumor Genomes. Chromosomal aberrations Structural : translocations, inversions, fissions, fusions. Copy number changes : gain and loss of chromosome arms, segmental duplications/deletions. Tumor Genomes. Mutation and selection . Compromised genome

Epidermal Growth Factor Receptor…. PDB ID: 1M14 (X-ray crystallography) . PDB ID: 1IVO (x-ray crystallography. Michelle McBride Molecular Anatomy Project . …is:. Picture here of structure diagram? Or next slide? . A transmembrane receptor glycoprotein

How can you benefit from the Bioinformatics Resource?. Can (John) Bruce, Ph.D. Associate Director Bioinformatics Resource Keck Biotechnology Laboratory. The Bioinformatics Core. Created within Keck Lab upon request from Yale School of Medicine, July 2007.

A. Synthetic siRNA against STAT3. 5’-CAU CUG CCU AGA UCG GCU AdTdT-3’ 3’-dTdT GUA GAC GGA UCU AGC CGA U- 5’. Vehicle Stat3 siRNA GFP siRNA. Vehicle Stat3 siRNA GFP siRNA. Vehicle Stat3 siRNA. B. a -STAT3 a - b -actin. a -STAT3 a -MAPK. A172. U251. NHA. C.

2 mM GlcN. A. 0 h. 2 h. 4 h. 8 h. 12 h. 24 h. p(Y705)Stat3. Stat3. Actin. 2 mM GlcN. Controls. B. 1 h. 0 h. 4 h. 8 h. Stat3. 1. 2. 3. 4. 5. 6. 7. 8. C.

STAT3 基因在 CD4 ＋ T 细胞介导抗肿瘤免疫中的重要作用. 作者姓名（排序）： Yanwei Shen, Weiyi Peng, Yoshihiro Miyahara, Shu Zheng, Rong-Fu Wang, and Helen Y. Wang 作者单位：浙江大学肿瘤研究所 第一作者姓名及身份证号码：沈彦伟 330102198110071215 通讯作者姓名：郑树，王荣福. 背景. STAT 家族是介导细胞因子、生长因子信号通路上启动蛋白转录的重要转录因子，它们在许多信号通路的细胞分子事件中都起到重要作用，例如细胞分化、细胞增殖和存活。

A. Empty vector. LepRb. Empty vector. LepRb. Leptin: - - - + + + - - - + + +. Leptin: - - - + + + - - - + + +. pSTAT3 (Y705). STAT3. 5 minutes of treatment. 15 minutes of treatment. 0.2. 0.18. pcDNA3-Co. 0.16.

STAT3. Michael Patel. Overview. STAT3 is a transcription activator It homodimerizes and binds to the DNA promoter region It is associated with oncogenesis, cellular differentiation, and embryogenesis. STAT3 Signaling Pathway. Involved in signal transduction pathway

Cross linking protein/DNA. Cells. Shear DNA strands by sonification. Immunopeecipitation with bead attached anti-STAT3 antibodies. Reverse crosslinks. Sequence. Align to genome. Read genomic coordinates of STAT3 binding. Read miR promoter genomic coordinates. Figure S1.

STAT3 and the Immune System. Maureen Sherry Lynes February 29, 2012. Overview. STAT family; STAT3 signaling and structure Role of STAT3 revealed by tissue specific knockouts STAT3 and the anti-tumor immune response Therapeutic approaches for targeting STAT3 Paper discussion.