'Stat3' diaporamas de présentation

Rearrangements and Duplications in Tumor Genomes

Rearrangements and Duplications in Tumor Genomes. Chromosomal aberrations Structural : translocations, inversions, fissions, fusions. Copy number changes : gain and loss of chromosome arms, segmental duplications/deletions. Tumor Genomes. Mutation and selection . Compromised genome

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How can you benefit from the Bioinformatics Resource?

How can you benefit from the Bioinformatics Resource?. Can (John) Bruce, Ph.D. Associate Director Bioinformatics Resource Keck Biotechnology Laboratory. The Bioinformatics Core. Created within Keck Lab upon request from Yale School of Medicine, July 2007.

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STAT3 and the Immune System

STAT3 and the Immune System. Maureen Sherry Lynes February 29, 2012. Overview. STAT family; STAT3 signaling and structure Role of STAT3 revealed by tissue specific knockouts STAT3 and the anti-tumor immune response Therapeutic approaches for targeting STAT3 Paper discussion.

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STAT3

STAT3. Michael Patel. Overview. STAT3 is a transcription activator It homodimerizes and binds to the DNA promoter region It is associated with oncogenesis, cellular differentiation, and embryogenesis. STAT3 Signaling Pathway. Involved in signal transduction pathway

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STAT3 ??? CD4 ? T ???????????????

STAT3 ??? CD4 ? T ???????????????. ????????? Yanwei Shen, Weiyi Peng, Yoshihiro Miyahara, Shu Zheng, Rong-Fu Wang, and Helen Y. Wang ?????????????? ???????????????? 330102198110071215 ?????????????. ??. STAT ?????????????????????????????????????????????????????????????????????????

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Supporting Figure 1: Acute leptin and IL-6 treatments on pY-STAT3 phosphorylation in HuH7 cells.

A. Empty vector. LepRb. Empty vector. LepRb. Leptin: - - - + + + - - - + + +. Leptin: - - - + + + - - - + + +. pSTAT3 (Y705). STAT3. 5 minutes of treatment. 15 minutes of treatment. 0.2. 0.18. pcDNA3-Co. 0.16.

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cont

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Vehicle Stat3 siRNA

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8 h

2 mM GlcN. A. 0 h. 2 h. 4 h. 8 h. 12 h. 24 h. p(Y705)Stat3. Stat3. Actin. 2 mM GlcN. Controls. B. 1 h. 0 h. 4 h. 8 h. Stat3. 1. 2. 3. 4. 5. 6. 7. 8. C.

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Read genomic coordinates of STAT3 binding

Cross linking protein/DNA. Cells. Shear DNA strands by sonification. Immunopeecipitation with bead attached anti-STAT3 antibodies. Reverse crosslinks. Sequence. Align to genome. Read genomic coordinates of STAT3 binding. Read miR promoter genomic coordinates. Figure S1.

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