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This study examines the differences in response to 5-fluorouracil (5-FU) treatment between parental and 5-FU-resistant colorectal cancer cell lines. Utilizing Affymetrix Plus 2.0 microarray technology, we analyze gene expression changes at 0 and 24 hours post-treatment. The insights gained from this research aim to enhance understanding of resistance mechanisms in colorectal cancer, potentially guiding more effective therapeutic strategies for resistant tumors.
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Additional File 1 Affymetrix Plus2.0 Colorectal DSA A. 5-FU treated 5-FU treated 0 24 Time (h) 0 24 Time (h) Sensitive Expt Parental Parental Resistant Expt 5-FU-resistant 5-FU-resistant