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Expansile Osteolytic Mass of Medial Sesamoid: Insights from Imaging and Excision Results

This case report details the presentation and management of a patient with right foot pain due to an expansile osteolytic mass at the medial sesamoid of the hallux. Initial CT suggested differential diagnoses including chondroblastoma or giant cell tumor. MRI findings highlighted irregular enhancement and bony erosion, leading to surgical excision. Pathological analysis confirmed calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, highlighting the importance of accurate imaging and diagnosis in similar cases.

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Expansile Osteolytic Mass of Medial Sesamoid: Insights from Imaging and Excision Results

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  1. Case • M/23 • C.C. : 1st MTP joint pain (1YA)

  2. 20070210 Foot AP/ sesamoid

  3. 20061202 Outside CT (Rt. Foot)

  4. Radiologic findings-CT • Expansile osteolytic mass at medial sesamoid of hallux - with suspicious fracture lines -> DDx) 1. chondroblastoma or GCT 2. ABC 3. intraosseous gout • Rec) Rt foot MRI using microcoil

  5. T1 sagittal T1 coronal T1 sagittal (FS/Gd+) 20070220 Foot MRI (Rt.)_Contrast

  6. T1 axial T2 axial T1 axial (FS/Gd+) 20070220 Foot MRI (Rt.)_Contrast

  7. Radiologic findings-MRI • Expansile mass involving medial sesamoid of hallux - peripheral irregular thick enhancement and central nonenhancing cystic or necrotic area - with its associated synovial enhancement of lst MTP joint - with bony erosion at lst metatarsal neck c reactive bone marrow edema • vascular structures anterior to the mass • closely abutting flexor hallucis tendon ->DDx) 1. intraosseous gout,most likely 2. tbc 3. tumorous condition such as giant cell tumor or chondroblastoma

  8. Hospital course • Op: Excision of Sesamoid, Rt.(2007-02-26) • Pathologic diagnosis • Soft tissue, right foot, excision • 1. Numerous rhomboid crystals showing birefringence • 2. Some foci of calcium deposit • 3. Chronic granulomatous inflammation            with 1) multinucleated giant cells                  2) central hyaline degeneration consistent with calcium pyrophosphate dihydrate deposition disease 

  9. Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease • Etiology • Idiopathic: most common • Increased with age (7% of population near age 70 and 30-60% by the age 80) • Hereditary: autosomal dominant condition • Maybe associated with ANK(chromosome 5p15) • Secondary: 5-10% of patients have metabolic disease. • Hyperparathyroidism, Hemochromatosis, Hypophosphatasia… • Clinical patterns • Asymptomatic chondrocalcinosis • CPPD crystal arthropathy • Pseudogout (18%), pseudo-osteoarthritis with/without synovitis (40%/18%), pseudorheumatoid arthritis (8%) • Common location: Knee, wrist, MCP joint Seminars in musculoskeletal radiology 2003;07:175-186

  10. Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease • Diagnositic imagings • Conventional radiography • Calcification within or around joints • Chondrocalcinosis • Synovial and capsular calcifications • Other soft tissue calcification • Findings of pyrophosphate arthropathy • Bilateral, symmetrical involvement of affected articulations • Cartilage loss, subchondral plate sclerosis, subchondral cyst formation • Subchondral collpase, fragmentation, intra-articular loose body • MRI • Less dense calcium deposition->GRE sequence is more sensitive than conventional radiography. Seminars in musculoskeletal radiology 2003;07:175-186

  11. Seminars in musculoskeletal radiology 2003;07:175-186

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