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Cytotoxicity of NKL Cells Against IFN-α-Treated HepG2 Cells: Implications for HCC Therapy

This study investigates the cytotoxic effects of NKL cells on HepG2 hepatocellular carcinoma (HCC) cells treated with 200 pg/ml of IFN-α for 6 hours. Following treatment, NKL cells were assessed for their cytotoxic potential against IFN-α-pretreated HepG2 cells. Results indicate significant differences in cytotoxicity between NKL-IFNα and NKL-vec cells, highlighting the enhanced effectiveness of the former. Additionally, the expression levels of HLA-ABC on HepG2 cells post co-culture with NKL cells were evaluated, providing insights into immune response modulation in HCC.

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Cytotoxicity of NKL Cells Against IFN-α-Treated HepG2 Cells: Implications for HCC Therapy

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  1. 160 NKL/HepG2 NKL/HepG2+IFN- 140 120 N.S. N.S. 100 80 Cytotoxicity% 60 40 20 0 10:1 5:1 E:T Fig S1.Cytotoxicity of NKL cells against IFN--treated HCC cells.HepG2 cells was pretreated with 200pg/ml IFN- for 6 h, and then exposed to parental NKL cells for cytotoxicity assay after washing off the IFN-. Data shown are means±SD from at least three separate experiments. *P<0.05, **P<0.01 versus NKL-vec cells.

  2. HepG2/NKL-vec HepG2/NKL-IFN HLA-ABC Fig S2.Expression of HLA-ABC on HepG2 cells. HepG2 cells were co-cultured with NKL-IFNor NKL-vec cells by transwell method. After 24 h, the expression levels of HLA-ABC in HepG2 cells were determined by FACS.One representative of at least three independent experiments.

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