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NSC WG 2 Hazard Identification

NSC WG 2 Hazard Identification. Progress report 26 February 2013, Prague Chair: Flemming R. Cassee Teresa Fernandes. Wish list. Information exchange of methods available within the Cluster Sharing protocols for testing if appropriate Harmonised methods/requirements for

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NSC WG 2 Hazard Identification

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  1. NSC WG 2 Hazard Identification Progress report 26 February 2013, Prague Chair: Flemming R. Cassee Teresa Fernandes

  2. Wish list Information exchange of methods available within the Cluster Sharing protocols for testing if appropriate Harmonised methods/requirements for kinetic investigation appropriate toxicological endpoints appropriate in vitro tests (e.g. cell lines) Comparison in-vitro versus in-vivo results Validation of appropriate testing methods including identification of limitations Requirements for screening tests Description of correlation between biological effects and material properties (cooperation Working Group 1) bioavailability/bioaccumulation/ADME and NP properties (cooperation Working Group 1) biological effects and exposure aspects and LCA (cooperation Working Group 3) Provision of results and outcome to the database (cooperation Working Group 4) 2 NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  3. Some items wish list now at • Four focus groups • Immunosafety focus group • Marine Ecotox focus group • BiomembraneNanosafety focus group • Genotoxicity Focus group 3 NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  4. Tasks • Information exchange of methods available within the Cluster • Methods/requirements for appropriate toxicological endpoints • Methods/requirements for appropriate in vitro tests (e.g. cell lines) • Sharing protocols for testing if appropriate • Established an on line protocol database /submission option: http://www.nanosafetycluster.eu/working-groups/2-hazard-wg/protocol-database.html • Flemming Cassee NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  5. Tasks • Harmonised methods/requirementsfor biokinetic investigation • A list of research groups that perform biokinetic studies including the contact person and a short description of the experimental design and studies nanomaterials will be compiled. • Review on recent biodistribution studies (work in progress) • Dave Spurgeon • Create summaries of key results for further use by the dissemination group (cooperation Working Group 7) • Revised to sharing summeries from scientific meetings • Members provide input for the NanoVision 2020 document • Teresa Fernandes NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  6. Focus group: Immunosafety • Diana Boraschi, Albert Duschl and Bengt Fadeel • Involve the excellent immunological expertise in Europe: • DB chairing a workshop at the International Congress of Immunology August 2013 • Disseminate the concept of immunosafety among nanotoxicologists • DB and AD writing an “immunology manual for nanotoxicologists” (Elsevier) • BF and DB writing a chapter on nanoparticles and the immune system for the second edition of “Nanotoxicology” (Informa Healthcare) • David Pozo Pérez launching a series of Special Focus Papers on interaction between nanoparticles and immune system on Journal of Nanoparticle Research • DB & AD joining with the leaders of the Marine Ecotox Focus Group in a Opinion paper on immunity of environmental species as key issue of nano-ecotoxicology • DB and AD proposing a ESF/EMBO course of immunosafety of nanomaterials • DB delivering a lesson on immunosafety at the 4th Nanosafety School in March 2013 • Standardising immunosafety assays • Andrea Haase leading in Qnano the Task of immunoassay standardisation • Peter Hoet and DB developing and validating endotoxin assessment assays for nanoparticles NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  7. Focus group Marine Ecotox • IlariaCorsi Joint initiative between the two focus groups immunology and marine ecotox, • a position paper on immune responses of environmental species (Teresa). NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  8. Focus groups • Biomembranes • Andrew Nelson • Genotoxicity • Maria Dusinska NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  9. Other • Symposium on Safety issues and regulatory challenges of nanomaterials - May 2012 • Socorro Vázquez-Campos (NANOPOlYTOX), Sergio Moya (HINAMOX), Maria Blázquez (NEPHH), Lang Tran (ENPRA) and Juan RiegoSintes (JRC) • Input to the Strategic Research Agenda / NanoVision 2020 Future • Organize a meeting, best done as a satellite to a meeting where many members will come anyway. • E.g. a joint meeting of NanoValid and MARINA, • E.g. Joint meeting NanoMile and NanoSolutions • Nanotoxicology 2014 NSC WG2 Hazard Indentification – 26 Feb 2013 Prague

  10. NSC WG 2 Hazard Identification Progress report 26 February 2013, Prague Chair: Flemming R. Cassee Teresa Fernandes

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