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Two point mutations convert native receptor into DREADD
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Two point mutations convert native receptor into DREADD. hM3D( Gq ) is Gq coupled DREADD. It is derived from human muscarinic receptor M3 sequence with two point mutations ( Y149C, A239G )
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Two point mutations convert native receptor into DREADD
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Presentation Transcript
Two point mutations convert native receptor into DREADD • hM3D(Gq) is Gq coupled DREADD. It is derived from human muscarinic receptor M3 sequence with two point mutations (Y149C, A239G) • hM4D(Gi) is Gi coupled DREADD. It is derived from human muscarinic receptor M4 sequence with two point mutations (Y113C, A203G) • rM3D(Gs)is Gs coupled DREADD. It is derived from rat muscarinic receptor M3 sequence with replacement of i2andi3 loop with turkey β1 AR sequence. It also contains two point mutations (Y148C, A238G).
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