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DECREASE III

DECREASE III. Myocardial ischemia was significantly reduced with statin ( OR 0.53; 95% CI 0.32-0.88, p = 0.016) LDL (p < 0.001) and hs-CRP (p  0.001) were lower in statin arm Incidence of adverse events was similar. (p = 0.016). (p = 0.039). Fluvastatin XL (n = 250). Placebo

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DECREASE III

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  1. DECREASE III Myocardial ischemia was significantly reduced with statin (OR 0.53; 95% CI 0.32-0.88, p = 0.016) LDL (p < 0.001) and hs-CRP (p  0.001) were lower in statin arm Incidence of adverse events was similar (p = 0.016) (p = 0.039) Fluvastatin XL (n = 250) Placebo (n = 247) Trial design: Patients undergoing noncardiac vascular surgery were randomized to fluvastatin XL or placebo, in addition to beta-blockers. Clinical outcomes were compared at 1 month. Results 19.0 20 20 15 15 Conclusions 10.9 % % 10.1 10 10 • Perioperative statin therapy was associated with improved outcomes in high-risk patients undergoing noncardiac vascular surgery • Results add to current literature on the benefit of statins in the perioperative period 4.8 5 5 0 0 Myocardial ischemia CV death or MI Presented by Dr. Don Poldermans at ESC 2008

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