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Amino Acids Metabolism 2 nd Year Medicine

Amino Acids Metabolism 2 nd Year Medicine. By Eman Mokbel Alissa, Ph.D. Lecture (1) content. Relationship to central metabolism Nitrogen disposal Transamination (aminotransferases/ transaminases) Glutamate dehydrogenase (amino acid oxidative deamination)

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Amino Acids Metabolism 2 nd Year Medicine

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  1. Amino Acids Metabolism2nd Year Medicine By Eman Mokbel Alissa, Ph.D.

  2. Lecture (1) content • Relationship to central metabolism • Nitrogen disposal • Transamination (aminotransferases/ transaminases) • Glutamate dehydrogenase (amino acid oxidative deamination) • Oxidative and nonoxidative deamination • Ammonia transport to liver • Glutamine cycle • Glucose- Alanine cycle

  3. Lecture (2) content • Urea Cycle • Urea Cycle importance and regulation • Metabolic Disorders of Urea Cycle • Sources and Fates of Ammonia • Transport of ammonia in the circulation • Hyperammonemia • Toxicity To Brain

  4. Lecture (3) content • Amino Acid Metabolic Classification • Catabolism of C skeleton of amino acids • Fate of C skeleton • Synthesis and Degradation of amino acids • Amino Acid Biological Classification • Non-essential amino acids synthesis • Metabolism of individual amino acids: • Glycine

  5. Lecture (4) Content • Metabolism of individual amino acids: • Branched chain amino acids • Arginine • Proline • Lysine • Serine • Histidine

  6. Lecture (5) Content • Metabolism of individual amino acids: • Phenylalanine • Tyrosine • Tryptophan

  7. Metabolism of individual amino acids: Aspartate Aspargine Glutamate Glutamine Alanine β-alanine Metabolism of individual amino acids: Cysteine Methionine S-adenosyl methionine Lecture (6) Content

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