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Tissue Engineering Initiative

Tissue Engineering Initiative. Drexel University & MCP Hahnemann University Philadelphia, PA. www.biomed.drexel.edu. Tissue Engineering at Drexel/MCPHU. College of Engineering. College of Medicine. Biomedical Engineering. Center for Advanced Bio- Materials & Tissue Engineering.

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Tissue Engineering Initiative

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  1. Tissue EngineeringInitiative Drexel University & MCP Hahnemann University Philadelphia, PA www.biomed.drexel.edu

  2. Tissue Engineering at Drexel/MCPHU College of Engineering College of Medicine Biomedical Engineering Center for Advanced Bio- Materials & Tissue Engineering Center for Fibrous Materials Research Implant Research Center Nanotechnology Center

  3. Tissue Engineering at Drexel/MCPHU Polymeric Scaffolds Matrix Development Cardiac & Neuro Tissue Engineering Cellular & Molecular Biology Replacement Organs Comp. Tissue Engineering Implant Research mg Bioreactors Nanofiber Composites Bone and Ligament Research Stem Cell Research

  4. Nanotechnology Center • $10.5M Nanotechnology Center will: • Nucleate sustained regional growth innano-biotechnology • Achieve national recognition in bio-nanoechnology

  5. Research Enterprise Building • Research Enterprise Building & Graduate Facilities • 150,000 ft2 of Modern facilities ($30M) theme-based laboratories including • Nano & Micro Technology • Biosensors • Tissue and Organ Engineering • Neuro Engineering

  6. Tissue A group of similar cells united to perform a specific function Engineering The design and manufacture of complex products through the application of science and mathematics Tissue Engineering Scientific American 280(4); April 1999

  7. Tissue Engineering Matrix Development Trabecular Bone Replacement Cato Laurencin, PhD , M.D. Moorehead Chair Professor Of Chemical Engineering and Biomedical Engineering Ligament Replacement Nanotechnology

  8. Tissue Engineering of Bone Cellular and Animal Studies

  9. Cellular Tissue Engineering Cellular/ Molecular Biology: Development and Differentiation Peter I. Lelkes, PhD, Calhoun Chair Professor of Cellular Tissue Engineering + Scaffolds/Nanotechnology Stem Cells Computer-Based Modeling Bioreactor Biotechnology (NASA) Functional Replacement Tissues

  10. Cellular Tissue Engineering:Primary Target Tissues/Organs • Cardiovascular Tissues: • Blood Vessels • Heart • Neural Tissues: • Brain • Peripheral Nerves • Endocrine Tissues: • Pancreas • Adrenal

  11. 3-D Nanofiber Scaffold for Tissue Engineered Cartilage Frank Ko, Ph.D Professor of Materials Engineering and Biomedical Engineering

  12. Micrometer Cone Assembly Stepper Motor Silicone Sleeve Glass Mandrel Base Unit z Well q a=0.5o r Cell-Seeded Construct Heating Element Circulation Ports Vascular Tissue Engineering Cell Mechanics & Tissue Engineering Kenneth A. Barbee, Ph.D Associate Professor of Biomedical Engineering Simulating the in vivo Mechanical Environment … to Promote the Development of Tissue Structure

  13. Atomic Force Microscopy for Measuring Mechanical Properties of Cells in Engineered Constructs Control of Smooth Muscle Injury During Angioplasty to Prevent Restenosis Mechanics of Neural Cell Injury and Acute Therapy for Preservation of Neural Function

  14. In vitro growth of encapsulated cells (genetically modified fibroblasts producing BDNF) Day 3 Day 7 Day 12 Immediately after encapsulation Other Members of the Cellular Tissue Engineering Team • Fred Allen • Assistant Professor of Biomedical Engineering • Cell matrix interactions for orthopedic applications • Cell motility and adhesion in tissue engineering • Michele Marcolongo • Associate Professor of Materials Engineering • Orthopedic biomaterials and tissue engineering(Partners: Rocky Tuan and Noreen Hickock, Orthopedic Surgery, Thomas Jefferson University) • Wei Sun • Assistant Professor of Mechanical Engineering • Computational tissue engineering and modelling • Margaret Wheatley • Professor of Biomedical Engineering • Responsive drug delivery for diabetes management • Nanofiber mat (Partner: Frank Ko) • Spinal cord repair (Partners: Itzhak Fisher and Marion Murray, Neurobiology, MCP Hahnemann University)

  15. IMPLANT RESEARCH INITIATIVE The implant research effort is the result of  a strategic research alliance of Drexel University with two medical partners, MCP Hahnemann and Thomas Jefferson Universities and two corporate partners, Exponent, Inc., and Stryker Howmedica Osteonics Corporation. Director: Steven Kurtz, Drexel University & Exponent Inc Associate Directors: Michele Marcolongo, Drexel University & Av Edidin, Howmedica Corp The goal of this initiative is to conduct research on implantable medical devices and to provide insight back to the surgical and engineering communities for improving the longevity of implants. The initial focus of is on orthopaedic total joint replacement and spinal implants. Future directions will include ophthalmic, dental, cardiovascular, and urologic implant research. Other Members of the Cellular Tissue Engineering Team (Cont.) • Yasha J. Kresh • Professor and Research Director, Cardiothoracic Surgery and Cardiovascular Biophysics & Computing, MCP Hahnemann & Drexel University • Complex cellular network dynamics (Partner: Banu Onaral) • Cardiac regenerative medicine January 15, 2001

  16. School of Biomedical Engineering,Science & Health Systems WWW.BIOMED.DREXEL.EDU Visit us on the web

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