1 / 25

Lipids

Lipids. 5. lipids : 1. have little or no affinity for water 2. contain C, H, O sometimes P 3. H:O never 2:1 4. types – fats, oils, phospholipids, steroids, and waxes. neutral lipids (a.k.a. triglycerides, fats, or oils) =

tavia
Télécharger la présentation

Lipids

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lipids

  2. 5. lipids: 1. have little or no affinity for water 2. contain C, H, O sometimes P 3. H:O never 2:1 4. types – fats, oils, phospholipids, steroids, and waxes neutral lipids (a.k.a. triglycerides, fats, or oils) = 3 fatty acids + 1 glycerol molecule

  3. Lipids • Lipids are composed of C, H, O (same elements as carbs but very diff structure/proportions & therefore very different biological properties) • long hydrocarbon chain • Diverse group • fats • phospholipids • steroids • Do not form polymers • big molecules made of subunit smaller molecules • not a continuing chain

  4. Fats • Structure: what makes them hydrophobic?: carboxyl group • glycerol (3C alcohol) + fatty acid • fatty acid = long HC “tail” with COOH group at “head” dehydration synthesis

  5. Fat • Triacylglycerol(big fat molecule!!) • 3 fatty acids linked to glycerol • ester linkage = between OH & COOH

  6. Dehydration synthesis (pulling the water out to free up the bond)

  7. Fats (Q: what happens when you add oil to water?) • Long HC chain • polar or non-polar? • hydrophilic or hydrophobic? • Function: • energy storage • very rich • 2x carbohydrates • cushion organs • insulates body • think whale blubber! “Let’s go to the video tape!” (play movie here)

  8. Saturated no double bonds found between carbon atoms on the fatty acid chains solid at room temperature at room temp., the molecules are packed closely together high melting point i.e. butter Unsaturated one or more double bonds present between carbon atoms on the fatty acid chains liquid at room temperature at room temp., the molecules cannot pack together closely enough to solidify because of the kinks caused by the double bonds low melting point i.e. olive oil Saturated Fats and Unsaturated Fats

  9. Saturated or Unsaturated? a) b) d) c)

  10. Saturated fats • All C bonded to H • No C=C double bonds • long, straight chain • most animal fats • solid at room temp. (mostly animal fats) • contributes to cardiovascular disease (atherosclerosis) = plaque deposits

  11. Unsaturated fats • C=C double bonds in the fatty acids • plant & fish fats • vegetable oils • liquid at room temperature • the kinks made by double bonded C prevent the molecules from packing tightlytogether

  12. i.e. peanut butter, margarine unsaturated fats have been synthetically converted to saturated fats by adding hydrogen prevent lipids from separating out in liquid (oil) form Hydrogenated Fats (TransFats)

  13. Structure of Phospholipids • glycerol + 2 fatty acids + PO4 • PO4 negatively charged • other small molecules may also be attached • adenine (ATP)

  14. this arrangement occurs spontaneously when added to water hydrophobic fatty acids meet “tail-to-tail” hydrophilic head groups interact water major components of all cell membranes The Arrangement of Phospholipids in Cell Membranes

  15. Phospholipids • Hydrophobic or hydrophilic? • fatty acid tails = hydrophobic • PO4 = hydrophilic head • dual “personality” • interaction with H2O is complex • & very important!

  16. Phospholipids in water • Hydrophilic heads attracted to H2O • Hydrophobic tails “hide” from H2O • self-assemble into aggregates • micelle • liposome • early evolutionary stage of cell?

  17. Why is this important? • Phospholipids define outside vs. inside • Where do we find phospholipids in cells? • cell membranes

  18. Phospholipids & cells • Phospholipids of cell membrane • double layer = bilayer • hydrophilic heads on outside • in contact with aqueous solution • hydrophobic tails on inside • form core • forms barrier between cell & external environment

  19. a molecule from which other steroids, including the sex hormones are synthesized contains four fused (interlocking) rings a common component of animal cell membranes high levels of it in the blood may contribute to atherosclerosis Cholesterol, a Steroid

  20. Diversity in steroids

  21. Steroids • ex: cholesterol, sex hormones • 4 fused C rings • different steroids created by attachingdifferentfunctional groups to rings cholesterol

  22. From Cholesterol  Sex Hormones • What a big difference a little atom can make!

  23. Cholesterol • Important cell component • animal cell membranes • precursor of all other steroids • including vertebrate sex hormones • high levels in blood may contribute to cardiovascular disease

  24. Cholesterol helps keep cell membranes fluid & flexible

  25. Let’s build some Lipids!

More Related